Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Quercitrin
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Purity: 98.0%
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BioBioPha
China
Product Name: Quercitrin
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Quercitrin
Price: ￥448.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Quercitrin
Price: $280.0/20mg
Purity: 98.0%
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Taiwan Oyi peptide Co. Ltd
China
Product Name: QUERCITRIN
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
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522-12-3

522-12-3 structure

Name: Quercitrin
Chemical Name: quercitrin
CAS Number: 522-12-3
Molecular Formula: C₂₁H₂₀O₁₁
Molecular Weight: 448.377
Catalog: Natural product Flavonoids
Create Date: 2018-05-26 08:00:00
Modify Date: 2024-01-02 15:42:54
Quercitrin is a natural compound found in Tartary buckwheat with a potential anti-inflammation effect that is used to treat heart and vascular conditions.IC50 value:Target:In vitro: There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. [1] In vivo: ICR mice received CCl4 intraperitoneally with or without quercitrin co-administration for 4 weeks. Data showed that quercitrin significantly suppressed the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduced tissue plasminogen activator (t-PA) activity, enhanced the antioxidant enzyme activities and abrogated cytochrome P450 2E1 (CYP2E1) induction in mouse brains. [2]

Name	quercitrin
Synonyms	quercetin 3-O-α-L-rhamnopyranoside quercetin-3-L-rhamnoside 3-O-α-rhamnosylquercetine Quercetin 3-O-L-rhamnoside Quercitroside QUERCETIN 3-L-RHAMNOSIDE EINECS 208-322-5 Thujin 3,3',4',5,7-Pentahydroxyflavone 3-(6-deoxy-a-L-mannopyranoside) 4H-1-Benzopyran-4-one, 3-((6-deoxy-α-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy- 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-on 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one Quercetin 3-O-α-L-rhamnoside 2-(3,4-Dihydroxyphényl)-5,7-dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-4H-chromén-4-one Quercetin-3-O-α-L-rhamnopyranoside 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-benzopyran-4-one Quercimelin 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-6-deoxy-α-L-mannopyranoside Quercetin-3-rhamnoside 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy- Quercetrin FLAVIN Quercetin-3-O-rhamnoside 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-α-L-mannopyranoside usafcf-2 quercetin 3-O-rhamnoside MFCD00016932 3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one Quercitrin quercetin 3-rhamnoside

Description	Quercitrin is a natural compound found in Tartary buckwheat with a potential anti-inflammation effect that is used to treat heart and vascular conditions.IC50 value:Target:In vitro: There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. [1] In vivo: ICR mice received CCl4 intraperitoneally with or without quercitrin co-administration for 4 weeks. Data showed that quercitrin significantly suppressed the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduced tissue plasminogen activator (t-PA) activity, enhanced the antioxidant enzyme activities and abrogated cytochrome P450 2E1 (CYP2E1) induction in mouse brains. [2]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK) Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology
References	[1]. Cincin ZB, et al. Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line. Pathol Oncol Res. 2015 Apr;21(2):333-8. [2]. Ma JQ, et al. Quercitrin offers protection against brain injury in mice by inhibiting oxidative stress and inflammation. Food Funct. 2016 Jan 20;7(1):549-56. [3]. Li W, et al. Quercitrin ameliorates the development of systemic lupus erythematosus-like disease in a chronic graft-versus-host murine model. Am J Physiol Renal Physiol. 2016 Feb 24:ajprenal.00249.2015.

Density	1.8±0.1 g/cm3
Boiling Point	814.0±65.0 °C at 760 mmHg
Melting Point	174-183ºC
Molecular Formula	C₂₁H₂₀O₁₁
Molecular Weight	448.377
Flash Point	288.3±27.8 °C
Exact Mass	448.100555
PSA	190.28000
LogP	2.17
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.776
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UZ5950000

CHEMICAL NAME :: Quercitrin

CAS REGISTRY NUMBER :: 522-12-3

BEILSTEIN REFERENCE NO. :: 0068135

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H20-O11

MOLECULAR WEIGHT :: 448.41

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ& GQ IQ DO- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 166 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,297,1978

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UZ5950000

80229-08-9

522-12-3

Literature: Isobe, Takahiko; Kanazawa, Keiji; Fujimura, Makoto; Noda, Yukinao Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 10 p. 3239

Precursor 1
80229-08-9
DownStream 4
117-39-5 6014-42-2 3615-41-6 73-34-7

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