Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: LACTO-N-FUCOPENTAOSE III
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

25541-09-7

25541-09-7 structure

Name: Lacto-N-fucopentaose III
Chemical Name: N-[2-[3,5-dihydroxy-2-(hydroxymethyl)-6-(1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxyoxan-4-yl]oxy-6-(hydroxymethyl)-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl]acetamide
CAS Number: 25541-09-7
Molecular Formula: C₃₂H₅₅NO₂₅
Molecular Weight: 853.77
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldehyde Dehydrogenase (ALDH)
Create Date: 2016-04-06 08:36:24
Modify Date: 2024-01-09 18:05:47
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1].

Name	N-[2-[3,5-dihydroxy-2-(hydroxymethyl)-6-(1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxyoxan-4-yl]oxy-6-(hydroxymethyl)-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl]acetamide
Synonyms	LNFP III lacto-n-Fucopentaose III Lewis-X pentasaccharide 4)-D-Glc Lex-lactose

Description	Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH) Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO) Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> Arginase
In Vitro	Lacto-N-fucopentaose III glycan (LNFP-III; 50 μg/mL; 48 h) 诱导炎症单核细胞产生一氧化氮。Lacto-N-fucopentaose III 减少树突状细胞跨脑内皮的迁移[1]。 Lacto-N-fucopentaose III glycan (50 μg/mL; 48 h) 显著增加精氨酸酶 I (Aldh1a2)、醛脱氢酶 1、A2 亚家族 (Aldh1a2)、吲哚胺 2,3-双加氧酶 1 (Ido1) 和血红素加氧酶 1 (Homx1) mRNA的表达[1]。
In Vivo	Lacto-N-fucopentaose III glycan (50 μg/mouse; i.v.; twice a week for 2 weeks) 显著降低实验性自身免疫性脑脊髓炎 (EAE) 和中枢神经系统炎症的严重程度，并扭曲小鼠对 Th2 显性谱的外周免疫反应[1]。 Lacto-N-fucopentaose III (35 μg dextran conjugate/mouse; s.c.; daily for 2 weeks) 改善 Gulf War Illness 小鼠模型的急性和持续性海马突触可塑性和传递缺陷[2]。
References	[1]. Zhu B, et al. Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis. Clin Immunol. 2012 Mar;142(3):351-61. [2]. Brown KA, et al. Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model. Life Sci. 2021 Aug 15;279:119707.

Density	1.71g/cm3
Boiling Point	1264.6ºC at 760 mmHg
Molecular Formula	C₃₂H₅₅NO₂₅
Molecular Weight	853.77
Flash Point	718.6ºC
Exact Mass	853.30600
PSA	415.62000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.655

Hazard Codes	Xi

25541-09-7	60254-64-0
21973-23-9	7578-25-8
117978-16-2	24667-51-4
30517-76-1	14116-68-8
87003-65-4	67319-96-4