25541-09-7

25541-09-7 structure
25541-09-7 structure
  • Name: Lacto-N-fucopentaose III
  • Chemical Name: N-[2-[3,5-dihydroxy-2-(hydroxymethyl)-6-(1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxyoxan-4-yl]oxy-6-(hydroxymethyl)-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl]acetamide
  • CAS Number: 25541-09-7
  • Molecular Formula: C32H55NO25
  • Molecular Weight: 853.77
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldehyde Dehydrogenase (ALDH)
  • Create Date: 2016-04-06 08:36:24
  • Modify Date: 2025-08-25 17:38:16
  • Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1].

Name N-[2-[3,5-dihydroxy-2-(hydroxymethyl)-6-(1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxyoxan-4-yl]oxy-6-(hydroxymethyl)-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl]acetamide
Synonyms LNFP III
lacto-n-Fucopentaose III
Lewis-X pentasaccharide
4)-D-Glc
Lex-lactose
Description Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1].
Related Catalog
In Vitro Lacto-N-fucopentaose III glycan (LNFP-III; 50 μg/mL; 48 h) 诱导炎症单核细胞产生一氧化氮。Lacto-N-fucopentaose III 减少树突状细胞跨脑内皮的迁移[1]。 Lacto-N-fucopentaose III glycan (50 μg/mL; 48 h) 显著增加精氨酸酶 I (Aldh1a2)、醛脱氢酶 1、A2 亚家族 (Aldh1a2)、吲哚胺 2,3-双加氧酶 1 (Ido1) 和血红素加氧酶 1 (Homx1) mRNA的表达[1]。
In Vivo Lacto-N-fucopentaose III glycan (50 μg/mouse; i.v.; twice a week for 2 weeks) 显著降低实验性自身免疫性脑脊髓炎 (EAE) 和中枢神经系统炎症的严重程度,并扭曲小鼠对 Th2 显性谱的外周免疫反应[1]。 Lacto-N-fucopentaose III (35 μg dextran conjugate/mouse; s.c.; daily for 2 weeks) 改善 Gulf War Illness 小鼠模型的急性和持续性海马突触可塑性和传递缺陷[2]。
References

[1]. Zhu B, et al. Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis. Clin Immunol. 2012 Mar;142(3):351-61.  

[2]. Brown KA, et al. Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model. Life Sci. 2021 Aug 15;279:119707.  

Density 1.71g/cm3
Boiling Point 1264.6ºC at 760 mmHg
Molecular Formula C32H55NO25
Molecular Weight 853.77
Flash Point 718.6ºC
Exact Mass 853.30600
PSA 415.62000
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.655
Hazard Codes Xi
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