Lacto-N-fucopentaose III
Modify Date: 2024-01-09 18:05:47
Lacto-N-fucopentaose III structure
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Common Name | Lacto-N-fucopentaose III | ||
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| CAS Number | 25541-09-7 | Molecular Weight | 853.77 | |
| Density | 1.71g/cm3 | Boiling Point | 1264.6ºC at 760 mmHg | |
| Molecular Formula | C32H55NO25 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 718.6ºC | |
Use of Lacto-N-fucopentaose IIILacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1]. |
| Name | N-[2-[3,5-dihydroxy-2-(hydroxymethyl)-6-(1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxyoxan-4-yl]oxy-6-(hydroxymethyl)-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl]acetamide |
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| Synonym | More Synonyms |
| Description | Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1]. |
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| Related Catalog | |
| In Vitro | Lacto-N-fucopentaose III glycan (LNFP-III; 50 μg/mL; 48 h) 诱导炎症单核细胞产生一氧化氮。Lacto-N-fucopentaose III 减少树突状细胞跨脑内皮的迁移[1]。 Lacto-N-fucopentaose III glycan (50 μg/mL; 48 h) 显著增加精氨酸酶 I (Aldh1a2)、醛脱氢酶 1、A2 亚家族 (Aldh1a2)、吲哚胺 2,3-双加氧酶 1 (Ido1) 和血红素加氧酶 1 (Homx1) mRNA的表达[1]。 |
| In Vivo | Lacto-N-fucopentaose III glycan (50 μg/mouse; i.v.; twice a week for 2 weeks) 显著降低实验性自身免疫性脑脊髓炎 (EAE) 和中枢神经系统炎症的严重程度，并扭曲小鼠对 Th2 显性谱的外周免疫反应[1]。 Lacto-N-fucopentaose III (35 μg dextran conjugate/mouse; s.c.; daily for 2 weeks) 改善 Gulf War Illness 小鼠模型的急性和持续性海马突触可塑性和传递缺陷[2]。 |
| References |
| Density | 1.71g/cm3 |
|---|---|
| Boiling Point | 1264.6ºC at 760 mmHg |
| Molecular Formula | C32H55NO25 |
| Molecular Weight | 853.77 |
| Flash Point | 718.6ºC |
| Exact Mass | 853.30600 |
| PSA | 415.62000 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.655 |
| Hazard Codes | Xi |
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| LNFP III |
| lacto-n-Fucopentaose III |
| Lewis-X pentasaccharide |
| 4)-D-Glc |
| Lex-lactose |