78957-85-4

78957-85-4 structure

Name: A-3 hydrochloride
Chemical Name: N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide, Hydrochloride
CAS Number: 78957-85-4
Molecular Formula: C₁₂H₁₄Cl₂N₂O₂S
Molecular Weight: 321.22300
Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
Create Date: 2018-03-07 08:00:00
Modify Date: 2024-01-10 11:47:45
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1].

Name	N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide, Hydrochloride
Synonyms	a-3 hydrochloride

Description	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Neuronal Signaling >> CaMK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Research Areas >> Others Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase Signaling Pathways >> TGF-beta/Smad >> PKC
Target	CK1:80 μM (Ki) CK2:5.1 μM (Ki) PKC:47 μM (Ki) PKA:4.3 μM (Ki)
In Vitro	A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1].
References	[1]. Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol. 1986 Jun;29(6):577-81.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport