A-3 hydrochloride
Modify Date: 2024-01-10 11:47:45
A-3 hydrochloride structure
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Common Name | A-3 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 78957-85-4 | Molecular Weight | 321.22300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H14Cl2N2O2S | Melting Point | 173-176ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of A-3 hydrochlorideA-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1]. |
| Name | N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide, Hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1]. |
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| Related Catalog | |
| Target |
CK1:80 μM (Ki) CK2:5.1 μM (Ki) PKC:47 μM (Ki) PKA:4.3 μM (Ki) |
| In Vitro | A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1]. |
| References |
| Melting Point | 173-176ºC |
|---|---|
| Molecular Formula | C12H14Cl2N2O2S |
| Molecular Weight | 321.22300 |
| Exact Mass | 320.01500 |
| PSA | 80.57000 |
| LogP | 4.70420 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| a-3 hydrochloride |