887781-62-6

887781-62-6 structure

Name: MK-0674
Chemical Name: Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-1-[4'-[(1R)-2,2-difluoro-1-hydroxyethyl][1,1'-biphenyl]-4-yl]-2,2,2-trifluoroethyl]amino]-4-fluoro-4-methyl-, (2S)
CAS Number: 887781-62-6
Molecular Formula: C₂₆H₂₇F₆N₃O₂
Molecular Weight: 527.50200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
Create Date: 2017-08-30 16:06:16
Modify Date: 2024-01-11 02:46:52
MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S. MK-0674 exhibits long half-lives in rats, rabbits and rhesus monkeys[1].

Name	Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-1-[4'-[(1R)-2,2-difluoro-1-hydroxyethyl][1,1'-biphenyl]-4-yl]-2,2,2-trifluoroethyl]amino]-4-fluoro-4-methyl-, (2S)

Description	MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S. MK-0674 exhibits long half-lives in rats, rabbits and rhesus monkeys[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
Target	IC50: 0.4 nM (Cathepsin K)[1]
In Vitro	MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM[1].
References	[1]. Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.