MK-0674
Modify Date: 2024-01-11 02:46:52
MK-0674 structure
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Common Name | MK-0674 | ||
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| CAS Number | 887781-62-6 | Molecular Weight | 527.50200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H27F6N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-0674MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S. MK-0674 exhibits long half-lives in rats, rabbits and rhesus monkeys[1]. |
| Name | Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-1-[4'-[(1R)-2,2-difluoro-1-hydroxyethyl][1,1'-biphenyl]-4-yl]-2,2,2-trifluoroethyl]amino]-4-fluoro-4-methyl-, (2S) |
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| Description | MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S. MK-0674 exhibits long half-lives in rats, rabbits and rhesus monkeys[1]. |
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| Related Catalog | |
| Target |
IC50: 0.4 nM (Cathepsin K)[1] |
| In Vitro | MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM[1]. |
| References |
| Molecular Formula | C26H27F6N3O2 |
|---|---|
| Molecular Weight | 527.50200 |
| Exact Mass | 527.20100 |
| PSA | 85.15000 |
| LogP | 6.30608 |