3153-55-7
3153-55-7 structure
- Name: O-Nornuciferine
- Chemical Name: (R)-1-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol
- CAS Number: 3153-55-7
- Molecular Formula: C18H19NO2
- Molecular Weight: 281.349
- Catalog: Natural product Alkaloid
- Create Date: 2016-11-18 01:49:30
- Modify Date: 2025-08-25 00:57:20
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O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor[1].
| Name | (R)-1-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol |
|---|---|
| Synonyms |
4H-Dibenzo[de,g]quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-6-methyl-, (6aR)-
(6aR)-1-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol |
| Description | O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor[1]. |
|---|---|
| Related Catalog | |
| In Vitro | O-Nornuciferine has an IC50 of 7.91 μM in vitro hERG blockages measured in HEK293 cells[1]. O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 451.4±45.0 °C at 760 mmHg |
| Melting Point | 195-197℃ (ethyl acetate ) |
| Molecular Formula | C18H19NO2 |
| Molecular Weight | 281.349 |
| Flash Point | 226.8±28.7 °C |
| Exact Mass | 281.141571 |
| PSA | 32.70000 |
| LogP | 3.36 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.634 |
| Hazard Codes | Xi |
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