O-Nornuciferine

Modify Date: 2026-08-01 15:16:11

O-Nornuciferine structure	Common Name	O-Nornuciferine
	CAS Number	3153-55-7	Molecular Weight	281.349
	Density	1.2±0.1 g/cm3	Boiling Point	451.4±45.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₉NO₂	Melting Point	195-197℃ (ethyl acetate )
	MSDS	N/A	Flash Point	226.8±28.7 °C

Use of O-Nornuciferine

O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor[1].

Name	(R)-1-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol
Synonym	More Synonyms

Description	O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	O-Nornuciferine has an IC50 of 7.91 μM in vitro hERG blockages measured in HEK293 cells[1]. O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids[1].
References	[1]. Ulrike Grienke, et al. Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids From Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements. J Agric Food Chem. 2015 Jun 17;63(23):5634-9.

Density	1.2±0.1 g/cm3
Boiling Point	451.4±45.0 °C at 760 mmHg
Melting Point	195-197℃ (ethyl acetate )
Molecular Formula	C₁₈H₁₉NO₂
Molecular Weight	281.349
Flash Point	226.8±28.7 °C
Exact Mass	281.141571
PSA	32.70000
LogP	3.36
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.634
InChIKey	AKXOIHNFHOEPHN-CQSZACIVSA-N
SMILES	COc1c(O)cc2c3c1-c1ccccc1CC3N(C)CC2

Hazard Codes	Xi

Name: Inhibition of melanogenesis in mouse B16-4A5 cells at 10 uM after 72 hrs by spectroph...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2317249

Name: Inhibition of melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs by spectroph...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2317248

Name: Inhibition of melanogenesis in mouse B16-4A5 cells at 100 uM after 72 hrs by spectrop...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2317247

Name: Antimelanogenic activity in mouse B16-4A5 cells assessed as inhibition of tyrosinase ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2317242

Name: Antimelanogenic activity in mouse B16-4A5 cells assessed as inhibition of tyrosinase ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2317241

Name: Antimelanogenic activity in mouse B16-4A5 cells assessed as inhibition of tyrosinase ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2317240

Name: Antimelanogenic activity in mouse B16-4A5 cells assessed as inhibition of TRP1 mRNA e...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2317239

Name: Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry
Source: ChEMBL
Target: N/A
External Id: CHEMBL2317246

Name: Cytotoxicity against mouse B16-4A5 cells assessed as cell viability at 30 uM after 70...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2317245

Name: Cytotoxicity against mouse B16-4A5 cells assessed as cell viability at 100 uM after 7...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2317244

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(6aR)-1-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.