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56-34-8

56-34-8 structure
56-34-8 structure
  • Name: Tetraethylammonium chloride
  • Chemical Name: tetraethylammonium chloride
  • CAS Number: 56-34-8
  • Molecular Formula: C8H20ClN
  • Molecular Weight: 165.704
  • Catalog: Chemical reagent Organic reagent Amine salt (ammonium salt)
  • Create Date: 2018-02-28 08:00:00
  • Modify Date: 2026-07-01 12:40:27
  • Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties[1][2].
Name tetraethylammonium chloride
Synonyms TETRAETHYLAMINEHYDROCHLORIDE
TETRAETHYLAMMONIUM CHLORIDE NICOTINIC BL OCKING AG
TETRAETHYLAMMONIUM CHLORIDE BIOULTRA
TetraethylaMMoniuM chloride hydrate, R
Tetraethylammonium
n,n,n-triethyl-ethanaminiuchloride
Tetraethylammonium chloride(TEAC)
tetraethylazaniuM chloride
Tetraethylammonium Chloride [N2,2,2,2]Cl
tetraethyl-ammoniuchloride
MFCD00011828
Ethamon chloride
TEAC)TetraethylaMMoniuM chlo
Ethanaminium,N,N,N-triethyl-,chloride
TETRAETHYLAMMONIUM CHLORIDE, ELECTRO-CHE MICAL ADE
Tetraethylammonium chloride, 10 mM in DMSO
Tetraethylammonium chloride (TEA), non-selective K+ channel blocker
ETAMON CHLORIDE
TETRAETHYLAMMONIUM CHLORIDE HYDRATE
Tetraethyl ammonium chloride
TETRAETHYLAMMONIUM CHLORIDE
Tetraethylammonium chloride,TEA chloride
AMMONIUM,TETRAETHYL-,CHLORIDE
n,n,n-triethylethanaminiumchloride
Tetraethylammonium chloride ., electrochemical ade, >= (AT)
ammonium chL
TEA CHLORIDE
Tetraethylammonium chloride Vetec(TM) ade
TETRAETHYLAMMONIUM CHLORIDE, FOR MOLECUL BIOLOGY
Tetraethylammonium chloride (TEA)
Tetraethylammonium chloride (6CI, 7CI)
EINECS 200-267-5
Tetraethylaminium·chloride
tetraethylazaniuM dihydrochloride Manganese chloride
N,N,N-Triethylethanaminium chloride
SKL1479
TETRAETHYLAMMONIUMCHLORIDE,MONOHYDRATE,CRYSTAL
Fourethyl aMMoniuM chloride
N,N,N,N-Tetraethylammoniumchloride
teac
TETRA ETHYL AMMONIUM CHLORIDE TEACL
Ethanaminium, N,N,N-triethyl-, chloride (1:1)
N2,2,2,2Cl
TETRAETHYLAMMONIUM CHLORIDE SOLUTION
Tetraethylammonium Chloride >
Tetraethylammonium chloride monohydrate
N,N,N,N-Tetraethylammonium chloride
TEAC
TetraethylaMMoniuM chlorid
etraethylammonium Chloride
Description Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties[1][2].
Related Catalog
In Vitro Tetraethylammonium (0.2-60 mM; 24-72 hours; C6 and 9L glioma cells) treatment inhibits the proliferation of C6 and 9L cells in a dose- and time-dependent manner[1]. Tetraethylammonium (40 mM; 24-72 hours; C6 and 9L glioma cells) treatment significantly increases apoptosis in cells[1]. Tetraethylammonium (40 mM; 12-48 hours; C6 and 9L glioma cells) treatment significantly elevates Bax/Bcl-2 protein ratio in a time-dependent manner[1]. The generation of intracellular ROS increased in C6 and 9L cells by the addition of 20 and 40 mM Tetraethylammonium[1]. Cell Proliferation Assay[1] Cell Line: Rat C6 and 9L glioma cells Concentration: 0.2 mM, 2 mM, 20 mM, 40 mM and 60 mM Incubation Time: 24 hours, 48 hours and 72 hours Result: Inhibited the proliferation of C6 and 9L cells in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: Rat C6 and 9L glioma cells Concentration: 40 mM Incubation Time: 24 hours, 48 hours and 72 hours Result: Significantly increased apoptosis in cells. Western Blot Analysis[1] Cell Line: Rat C6 and 9L glioma cells Concentration: 40 mM Incubation Time: 12 hours, 24 hours, 48 hours Result: The expression of Bax was markedly increased, while that of Bcl-2 showed a decreasing trend 12, 24 and 48 h.
In Vivo Tetraethylammonium (1 mM, 3 mM, and 5 mM) significantly increases the amplitude and frequency of contractility of colon and rectum from rats in longitudinal and circular direction. Tetraethylammonium at 5 mM and 15 mM concentrations shows no effect on histology of colon and rectum from rats that are administered locally with Tetraethylammonium into colon lumen from anus for 10 days[2].
References

[1]. K B Yang, et al. Tetraethylammonium inhibits glioma cells via increasing production of intracellular reactive oxygen species. Chemotherapy. 2009;55(5):372-80.

[2]. Zhe Li, et al. Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2011 Aug;384(2):147-55.
Density 1.08
Melting Point 39°C
Molecular Formula C8H20ClN
Molecular Weight 165.704
Exact Mass 165.128433
Storage condition Store at RT
Stability Stable. Incompatible with strong oxidizing agents. Protect from moisture.
Water Solubility methanol: 0.1 g/mL, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BS6125000
CHEMICAL NAME :
Ammonium, tetraethyl-, chloride
CAS REGISTRY NUMBER :
56-34-8
LAST UPDATED :
199701
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C8-H20-N.Cl
MOLECULAR WEIGHT :
165.74
WISWESSER LINE NOTATION :
2K2&2&2 &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - ptosis
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841- Volume(issue)/page/year: 213,572,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2630 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 78,708,1951
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
833 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 117,169,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 25,315,1925
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 117,169,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
36 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
58 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
3488 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness
REFERENCE :
SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX. Volume(issue)/page/year: 10,201,1900 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1275 mg/kg/22D-I
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84225 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 41 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84225 No. of Facilities: 65 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 461 (estimated) No. of Female Employees: 171 (estimated)
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS BS6125000
HS Code 29239000
HS Code 29239000
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