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Product Name: Tetraethylammonium chloride
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Dayang Chem (Hangzhou) Co., Ltd.
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tetraethylammonium Chloride
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56-34-8

56-34-8 structure

Name: Tetraethylammonium chloride
Chemical Name: tetraethylammonium chloride
CAS Number: 56-34-8
Molecular Formula: C₈H₂₀ClN
Molecular Weight: 165.704
Catalog: Chemical reagent Organic reagent Amine salt (ammonium salt)
Create Date: 2018-02-28 08:00:00
Modify Date: 2024-01-02 18:37:40
Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties[1][2].

Name	tetraethylammonium chloride
Synonyms	Tetraethyl ammonium chloride N,N,N,N-Tetraethylammonium chloride Tetraethylammonium chloride TEAC EINECS 200-267-5 Ethanaminium, N,N,N-triethyl-, chloride (1:1) MFCD00011828 N,N,N-Triethylethanaminium chloride

Description	Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	Tetraethylammonium (0.2-60 mM; 24-72 hours; C6 and 9L glioma cells) treatment inhibits the proliferation of C6 and 9L cells in a dose- and time-dependent manner[1]. Tetraethylammonium (40 mM; 24-72 hours; C6 and 9L glioma cells) treatment significantly increases apoptosis in cells[1]. Tetraethylammonium (40 mM; 12-48 hours; C6 and 9L glioma cells) treatment significantly elevates Bax/Bcl-2 protein ratio in a time-dependent manner[1]. The generation of intracellular ROS increased in C6 and 9L cells by the addition of 20 and 40 mM Tetraethylammonium[1]. Cell Proliferation Assay[1] Cell Line: Rat C6 and 9L glioma cells Concentration: 0.2 mM, 2 mM, 20 mM, 40 mM and 60 mM Incubation Time: 24 hours, 48 hours and 72 hours Result: Inhibited the proliferation of C6 and 9L cells in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: Rat C6 and 9L glioma cells Concentration: 40 mM Incubation Time: 24 hours, 48 hours and 72 hours Result: Significantly increased apoptosis in cells. Western Blot Analysis[1] Cell Line: Rat C6 and 9L glioma cells Concentration: 40 mM Incubation Time: 12 hours, 24 hours, 48 hours Result: The expression of Bax was markedly increased, while that of Bcl-2 showed a decreasing trend 12, 24 and 48 h.
In Vivo	Tetraethylammonium (1 mM, 3 mM, and 5 mM) significantly increases the amplitude and frequency of contractility of colon and rectum from rats in longitudinal and circular direction. Tetraethylammonium at 5 mM and 15 mM concentrations shows no effect on histology of colon and rectum from rats that are administered locally with Tetraethylammonium into colon lumen from anus for 10 days[2].
References	[1]. K B Yang, et al. Tetraethylammonium inhibits glioma cells via increasing production of intracellular reactive oxygen species. Chemotherapy. 2009;55(5):372-80. [2]. Zhe Li, et al. Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2011 Aug;384(2):147-55.

Density	1.08
Melting Point	39°C
Molecular Formula	C₈H₂₀ClN
Molecular Weight	165.704
Exact Mass	165.128433
Storage condition	Store at RT
Stability	Stable. Incompatible with strong oxidizing agents. Protect from moisture.
Water Solubility	methanol: 0.1 g/mL, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BS6125000

CHEMICAL NAME :: Ammonium, tetraethyl-, chloride

CAS REGISTRY NUMBER :: 56-34-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C8-H20-N.Cl

MOLECULAR WEIGHT :: 165.74

WISWESSER LINE NOTATION :: 2K2&2&2 &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - paresthesis Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - ptosis

REFERENCE :: AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841- Volume(issue)/page/year: 213,572,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2630 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 78,708,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 833 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 117,169,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 25,315,1925

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 117,169,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 3488 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness

REFERENCE :: SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX. Volume(issue)/page/year: 10,201,1900 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1275 mg/kg/22D-I

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,103,1948 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84225 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 41 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84225 No. of Facilities: 65 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 461 (estimated) No. of Female Employees: 171 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	BS6125000
HS Code	29239000

Precursor 10
2603-10-3 554-68-7 105-58-8 993-20-4
506-77-4 57812-16-5 12241-54-2 114636-07-6
18105-64-1 13435-20-6
DownStream 10
429-06-1 35895-69-3 118773-91-4 628-13-7
121-44-8 680-31-9 80631-19-2 7719-12-2
13536-48-6 13550-32-8

HS Code	29239000

56-34-8	68696-18-4
6024-76-6	10408-33-0
74077-58-0	6667-73-8
1450882-06-0	3765-12-6
17083-85-1	19680-50-3
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4
849349-65-1	127437-46-1