Name | palmatine |
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Synonyms |
Calystigine
7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium MFCD00221758 palmatine Burasaine 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium palmatin berbericinine 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy- o,o-dimethyldemethyleneberberine Hindarinine 5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium Common fibraurea stem |
Description | Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1]. |
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Related Catalog | |
Target |
IDO1 |
In Vitro | Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM[1]. |
In Vivo | Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1]. Animal Model: DSS- induced Colitis BALB/c mice model[1] Dosage: 50 or 100 mg/kg; 7 days Administration: Oral administration Result: Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells. |
References |
Melting Point | 205ºC |
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Molecular Formula | C21H22NO4+ |
Molecular Weight | 352.403 |
Exact Mass | 352.154327 |
PSA | 40.80000 |
LogP | -1.12 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | Xi |
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HS Code | 2933990090 |
~60% 3486-67-7 |
Literature: Bian, Xiaoli; He, Langchong; Yang, Guangde Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1380 - 1383 |
~20% 3486-67-7 |
Literature: Wafo, Pascal; Nyasse, Barthelemy; Fontaine, Catherine Phytochemistry, 1999 , vol. 50, # 2 p. 279 - 281 |
~% 3486-67-7 |
Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383 |
~% 3486-67-7 |
Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383 |
~% 3486-67-7 |
Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383 |
Precursor 2 | |
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DownStream 1 | |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |