21931-53-3

21931-53-3 structure

Name: Uridine 5'-diphosphate sodium salt
Chemical Name: Uridine 5,-Diphosphate Sodium Salt
CAS Number: 21931-53-3
Molecular Formula: C₉H₁₄N₂O₁₂P_2.xNa
Molecular Weight: 448.125
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-02-28 08:00:00
Modify Date: 2024-01-01 18:26:59
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

Name	Uridine 5,-Diphosphate Sodium Salt
Synonyms	Uridine, 5'-(trihydrogen diphosphate), sodium salt (1:2) Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}uridine trisodium,[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate MFCD00006524 Uridine 5'-diphosphate sodium salt

Description	Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2]. Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2]. Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2]. UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2]. Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2]. RT-PCR[2] Cell Line: Primary microglia Concentration: 100 μM Incubation Time: For 15 min Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.
References	[1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89. [2]. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.

Molecular Formula	C₉H₁₄N₂O₁₂P_2.xNa
Molecular Weight	448.125
Exact Mass	447.966095
PSA	243.12000
Appearance	Powder \| White
Storage condition	−20°C
Water Solubility	H2O: soluble100 mg/mL, clear, colorless to very faintly yellow \| Soluble in water to 100mM

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H371
Precautionary Statements	P260
Hazard Codes	Xn
Risk Phrases	R22;R48/22
Safety Phrases	36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29349990

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