Uridine 5'-diphosphate sodium salt

Modify Date: 2024-01-01 18:26:59

Uridine 5'-diphosphate sodium salt Structure
Uridine 5'-diphosphate sodium salt structure
Common Name Uridine 5'-diphosphate sodium salt
CAS Number 21931-53-3 Molecular Weight 448.125
Density N/A Boiling Point N/A
Molecular Formula C9H14N2O12P2.xNa Melting Point N/A
MSDS USA Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Use of Uridine 5'-diphosphate sodium salt


Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

 Names

Name Uridine 5,-Diphosphate Sodium Salt
Synonym More Synonyms

 Uridine 5'-diphosphate sodium salt Biological Activity

Description Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2]. Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2]. Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2]. UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2]. Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2]. RT-PCR[2] Cell Line: Primary microglia Concentration: 100 μM Incubation Time: For 15 min Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.
References

[1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89.

[2]. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.

 Chemical & Physical Properties

Molecular Formula C9H14N2O12P2.xNa
Molecular Weight 448.125
Exact Mass 447.966095
PSA 243.12000
Appearance of Characters Powder | White
Storage condition −20°C
Water Solubility H2O: soluble100 mg/mL, clear, colorless to very faintly yellow | Soluble in water to 100mM

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H371
Precautionary Statements P260
Hazard Codes Xn
Risk Phrases R22;R48/22
Safety Phrases 36/37
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29349990

 Preparation


 Articles2

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 Synonyms

Uridine, 5'-(trihydrogen diphosphate), sodium salt (1:2)
Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}uridine
trisodium,[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate
MFCD00006524
Uridine 5'-diphosphate sodium salt
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