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480-66-0

480-66-0 structure
480-66-0 structure
  • Name: 2',4',6'-Trihydroxyacetophenone Monohydrate
  • Chemical Name: 2',4',6'-trihydroxyacetophenone
  • CAS Number: 480-66-0
  • Molecular Formula: C8H8O4
  • Molecular Weight: 168.147
  • Catalog: Chemical reagent Organic reagent Aromatic ketone
  • Create Date: 2018-12-25 17:12:51
  • Modify Date: 2026-07-02 19:12:13
  • Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].
Name 2',4',6'-trihydroxyacetophenone
Synonyms 2-Acetylphloroglucinol, THAP
2’,4’,6’-Trihydroxyacetophenone
2,4,6-trihyroxyacetophenone
2-(2,4-dihydroxyphenyl)-2-hydroxy-1-phenylethanone
2-Acetyl-1,3,5-trihydroxybenzene
2',4',6'-Trihydroxyacetophenone hydrate
JR-13799, 1-(2,4,6-Trihydroxyphenyl)ethanone hydrate
6'-Trihydroxyacetophenone
Phloroacetophenone
2,4,6-TRIHYDROXYLACETOPHENONE
Acetophenone, 2',4',6'-trihydroxy- (8CI)
2,4,6-Trihydroxyacetophenone.H2O
2',4', 6'-Trihydroxyacetophenone Monohydrat
Phloracetophenone/2',4',6'-Trihydroxyacetophenone
2,4,6-Trihydroxy-1-acetylbenzene
2,4,6-trihydroxyacetophenone
2,4,6-Trihydroxyaetcophenone
MFCD00002287
2,4,6-TRIHYDROXYACETOPHENONE(PHLOROACETOPHENONE)
1-(2,4,6-trihydroxyphenyl)ethanone hydrate
2',4',6'-trihydroxyacetopheMone
Phloroacetophenonehydrate
2-Acetylphloroglucinol
EINECS 207-556-5
Acetophenone, 2',4',6'-trihydroxy
Acetophloroglucine
Acetophenone,2’,4’,6’-trihydroxy
2,4,6-trihydroxylacetophenone monohydrate
2,4,6-TRIHYDROXYACETOPHENONE MONOHYDRATE, PGE. WITH 10X
2-Acetylphloroglucinol,THAP
Phloroacetophenone Monohydrate
2',4',6'-Trihydroxyacetophenone (monohydrate/anhydrous)
1-(2,4,6-trihydroxyphenyl)ethan-1-one
Methyl-(2,4,6-trihydroxyphenyl) ketone
1-(2,4,6-Trihydroxyphenyl)-ethanone
1-(2,4,6-Trihydroxyphenyl)ethan-1-one, 2-Acetylbenzene-1,3,5-triol
1-(2,4-dihydroxyphenyl)-2-hydroxyethan-1-one
2',4',6'-Trihydroxyacetophenon
2-Acetylphloroglucinol Monohydrate
Monoacetylphloroglucinol
PHLOROACETOPHENONE
Phloracetophene
1-(2,4,6-trihydroxyphenyl)-ethanon
2',4',6'-Trihydroxyaceto-phenone
1-(2,4,6-TRIHYDROXYPHENYL)-ETHANONE
1-(2,4,6-Trihydroxyphenyl)ethanone
2-Acetylphloroglucinol Phloroacetophenone
Phloracetophenone
2',4',6'-Trihydroxyacetophenone
Phloroacetophenone monohydrate
2-Acetylphloroglucin
2',4',6'-Trihydroxya
Phloroglucinol Acetyl
2,4,6-TrihydroxyacetophenonMonohydrat
2',4',6'-Trihydroxyacetophenone monohydrate
Ethanone,1-(2,4,6-trihydroxyphenyl)
2',4',67-TRIHYDROXYACETOPHENONE MONOHYDR
2,4,6-Trihydroxyacetophenon
1-(2,4,6-tTihydroxyphenyl)ethanone
Acetylphloroglucinol
2-Acetylphloroglucinol hydrate
Description Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].
Related Catalog
Target

Cholesterol 7α-hydroxylase[1], Mrp2[2]

In Vitro Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level[1]. Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver[2].
In Vivo Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis[2].
References

[1]. Charoenteeraboon J, et al. Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone. Eur J Pharmacol. 2005 May 16;515(1-3):43-6.

[2]. Piyachaturawat P, et al. Choleretic activity of phloracetophenone in rats: structure-function studies using acetophenone analogues. Eur J Pharmacol. 2000 Jan 10;387(2):221-7.
Density 1.4±0.1 g/cm3
Boiling Point 333.2±22.0 °C at 760 mmHg
Melting Point 219-221 °C(lit.)
Molecular Formula C8H8O4
Molecular Weight 168.147
Flash Point 169.5±18.8 °C
Exact Mass 168.042252
PSA 77.76000
LogP 2.07
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.641
Storage condition Refrigerator
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AN0528000
HS Code 2942000000
HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
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