3943-74-6

3943-74-6 structure

Name: Methyl vanillate
Chemical Name: methyl vanillate
CAS Number: 3943-74-6
Molecular Formula: C₉H₁₀O₄
Molecular Weight: 182.173
Catalog: Chemical reagent Organic reagent Ester Methyl ester compound
Create Date: 2018-08-24 13:13:49
Modify Date: 2025-08-24 04:35:14
Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator[1]. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

Name	methyl vanillate
Synonyms	4-Hydroxy-3-methoxybenzoic Acid Methyl Ester Methyl 4-hydroxy-3-methoxybenzoate MFCD00008438 Benzoic acid, 4-hydroxy-3-methoxy-, methyl ester Vanillic Acid Methyl Ester Vanillic acid, methyl ester (8CI) Methyl vanillate EINECS 223-525-9

Description	Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator[1]. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Wnt Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology
Target	Wnt/β-catenin[1]
In Vitro	Methyl vanillate (0-100 μM) increases the expression and nuclear translocation of β-catenin in calvarial osteoblasts. Methyl vanillate dose-dependently elevates ALP activity in calvarial osteoblasts[1].
References	[1]. Cha PH, et al. Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. PLoS One. 2014 Jan 22;9(1):e85546.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06782

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DH2430000
HS Code	2918990090

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%