57469-78-0
57469-78-0 structure
- Name: Ketoprofen lysinate
- Chemical Name: Ketoprofen lysinate
- CAS Number: 57469-78-0
- Molecular Formula: C22H28N2O5
- Molecular Weight: 400.46800
- Catalog: Biochemical Amino acids and their derivatives Lysine derivative
- Create Date: 2018-09-25 14:17:13
- Modify Date: 2024-01-08 17:28:07
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Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].
| Name | Ketoprofen lysinate |
|---|---|
| Synonyms |
ketoprofen lysine salt
Lysyl-ketoprofen lysine-ketoprofen ketoprofen lysine |
| Description | Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
COX-1:2 nM (IC50) COX-2:26 nM (IC50) |
| In Vitro | Ketoprofen lysinate inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2)[1]. Ketoprofen lysinate (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells[3]. RT-PCR[3] Cell Line: LPS (0.2 μg/mL)-stimulated bovine mammary epithelial cells Concentration: 2.5 mg /mL Incubation Time: 3, 6, 24 h Result: Decreased the mRNA level of TNFα, IL-8, SAA, COX-2 and PTGES. |
| In Vivo | Ketoprofen lysinate (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%)[2]. Ketoprofen lysinate (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS[3]. Animal Model: HFD-induced obese C57BL/6 mice[2] Dosage: 10 mg/kg Administration: Oral administration, three times a week for 10 weeks Result: Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin. Animal Model: LPS (0.2 μg/mL)-treated dairy cows [3] Dosage: 50 mg/kg Administration: Injection (Milk samples were taken every 30 min until 6 and 9 h) Result: Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk. |
| References |
| Density | 1.198g/cm3 |
|---|---|
| Boiling Point | 431.3ºC at 760mmHg |
| Molecular Formula | C22H28N2O5 |
| Molecular Weight | 400.46800 |
| Flash Point | 228.8ºC |
| Exact Mass | 400.20000 |
| PSA | 143.71000 |
| LogP | 4.03360 |