- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Chonglou Saponin VII
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- BioBioPha
- China
- Product Name: Chonglou Saponin VII
- Price: ￥Inquiry/5mg
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Chonglou Saponin VII
- Price: ￥3200.0/5mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: CHONGLOU SAPONIN VII
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
68124-04-9
68124-04-9 structure
- Name: Chonglou Saponin VII
- Chemical Name: Chonglou Saponin VII
- CAS Number: 68124-04-9
- Molecular Formula: C51H82O21
- Molecular Weight: 1031.184
- Catalog: Natural product Steroidal compound
- Create Date: 2018-05-23 08:00:00
- Modify Date: 2024-01-03 06:36:46
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Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].
| Name | Chonglou Saponin VII |
|---|---|
| Synonyms |
(3β,25R)-17-Hydroxyspirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->4)]- Paris saponin VII |
| Description | Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1]. |
|---|---|
| Related Catalog | |
| Target |
Akt p38 Bcl-2 Caspase-9 Caspase-3 PARP-1 |
| In Vitro | Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase[1]. |
| In Vivo | Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C51H82O21 |
| Molecular Weight | 1031.184 |
| Exact Mass | 1030.534912 |
| PSA | 314.83000 |
| LogP | 4.91 |
| Index of Refraction | 1.629 |
| Storage condition | -20℃ |