274901-16-5
274901-16-5 structure
- Name: Vildagliptin (LAF-237)
- Chemical Name: Vildagliptin
- CAS Number: 274901-16-5
- Molecular Formula: C17H25N3O2
- Molecular Weight: 303.39900
- Catalog: API Circulatory system medication Regulating blood lipids
- Create Date: 2018-04-19 08:00:00
- Modify Date: 2026-07-01 19:28:14
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Vildagliptin (LAF-237; NVP-LAF 237) inhibits DPP-4 with IC50 of 2.3 nM.IC50 Value: 2.3 nM[1]Target: DPP-4in vitro: Vildagliptin is an N-substituted glycyl-2-cyanopyrrolidine (figure 2). It is a potent competitive and reversible inhibitor of human and rodent DPP-4 in vitro, with a median inhibitory concentration (IC50) ~2-3 nmol/L. Importantly, vildagliptin inhibits DPP-4 with high specificity relative to other similar peptidases where its IC50 exceeds 200 mol/L [1].in vivo: Compared to age-, gender-, BMI-matched subjects with normal renal function, the mean AUC of vildagliptin after 14 days in patients with mild, moderate, and severe RI increased by 40%, 71%, and 100%, respectively [2]. The treatment was effective in modulating stress in pancreatic tissue, both by reducing levels of stress markers as well as by increasing activity of SOD and catalase. After analyzing the pancreatic histology, we found that vildagliptin was also able to preserve islets and pancreatic β-cells, especially at the concentration of 5 mg/kg [3].Clinical trial: FDA approved drug.
| Name | Vildagliptin |
|---|---|
| Synonyms |
Vildagliptin DPP-4 inhibitor
Vildagliptin -HIS phma API Vildagliptin Unii-I6B4B2U96p Vildagliptin (2S)-1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]- 2-pyrrolidinecbonitrile Vildagliptin //BP (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]-acetyl]-pyrrolidin-2-carbonitrile Vildagliptin (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile Galvus (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile Vildaliptin Viggliptin API Vildagliptin Top quality API Vildagliptin with best price (2S)-1-((3-Hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile Vidaletin VildagliptinQ: What is Vildagliptin Q: What is the CAS Number of Vildagliptin Q: What is the storage condition of Vildagliptin Q: What e the applications of Vildagliptin LAF237; GALVUS; NVP-LAF 237; ZOMELIS Vildagliptin In-House dagL (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]pyrrolidine-2-carbonitrile Vildagliptin Supplier Vildagliptin IP/In-House 1-[2-(3-HydroxyadaMant-1-ylaMino)acetyl]pyrrolidine-2(S)-carbonitrile Best Quality Vildagliptin with best price CAS NO.274-5 (2S)-1-(2-((3-hydroxyadaMantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine Vildagliptin 、VildagliptinAPI (2S)-1-[N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile NVP-LAF Vildgliptin (S)-1-[2-[(3-Hydroxyadamant-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile Vildagliptin 2-Pyrrolidinecbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl] Vildagliptin - Bio-X Vigliptin 2-Pyrrolidinecbonitrile, 1-(((3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)amino)acetyl)-, (2S) (-)-(2S)-1-[[(3-Hydroxytricyclo [3.3.1.1[3,7]]dec-1-yl)amino] acetyl]pyrrolidine-2-carbonitrile 2-Pyrrolidinecbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S) Vildagliptin, 10 mM in DMSO VILDAGLIPTIN CAS NO:274-5 Vildagliptin Crude Vader column dean DSP7238 (S)-1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrrolidine-2-carbonitrile Vidagliptin (see vildagliptin) Laf 237 China Top quality Vildagliptin CAS NO.274-5 ZoMelis ethyl {2-amino-6-[(4-fluorobenzyl)amino]pyridin-3-yl}cbamate (2Z)-but-2-enedioate (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile Laf Vildagliptin API (S)-1-(2-(((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile (S)-1-[2-((5S,7S)-3-hydroxy-adaMantan-1-ylaMino)-acetyl]-pyrrolidine-2-carbonitrile Vildagliptin (API) 2-Pyrrolidinecbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl] |
| Description | Vildagliptin (LAF-237; NVP-LAF 237) inhibits DPP-4 with IC50 of 2.3 nM.IC50 Value: 2.3 nM[1]Target: DPP-4in vitro: Vildagliptin is an N-substituted glycyl-2-cyanopyrrolidine (figure 2). It is a potent competitive and reversible inhibitor of human and rodent DPP-4 in vitro, with a median inhibitory concentration (IC50) ~2-3 nmol/L. Importantly, vildagliptin inhibits DPP-4 with high specificity relative to other similar peptidases where its IC50 exceeds 200 mol/L [1].in vivo: Compared to age-, gender-, BMI-matched subjects with normal renal function, the mean AUC of vildagliptin after 14 days in patients with mild, moderate, and severe RI increased by 40%, 71%, and 100%, respectively [2]. The treatment was effective in modulating stress in pancreatic tissue, both by reducing levels of stress markers as well as by increasing activity of SOD and catalase. After analyzing the pancreatic histology, we found that vildagliptin was also able to preserve islets and pancreatic β-cells, especially at the concentration of 5 mg/kg [3].Clinical trial: FDA approved drug. |
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| Related Catalog | |
| References |
| Density | 1.27 g/cm3 |
|---|---|
| Boiling Point | 531.3ºC at 760 mmHg |
| Melting Point | 153-155?C |
| Molecular Formula | C17H25N3O2 |
| Molecular Weight | 303.39900 |
| Flash Point | 275.1ºC |
| Exact Mass | 303.19500 |
| PSA | 76.36000 |
| LogP | 1.50308 |
| Storage condition | -20°C Freezer |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2933990090 |
| Precursor 10 | |
|---|---|
| DownStream 0 | |
![1-[N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetyl]pyrrolidine-2-nitrile structure](https://image.chemsrc.com/caspic/034/1354835-83-8.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |