482-39-3

482-39-3 structure

Name: Afzelin
Chemical Name: afzelin
CAS Number: 482-39-3
Molecular Formula: C₂₁H₂₀O₁₀
Molecular Weight: 432.378
Catalog: Natural product Flavonoids
Create Date: 2018-04-18 08:00:00
Modify Date: 2026-07-01 22:33:19
Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1. Afzelin improves the survival rate and reduces the serum levels of alanine aminotransferase and pro-inflammatory cytokines in D-galactosamine (GalN)/LPS -treated mice[1].

Name	afzelin
Synonyms	kaempferol-3-rhamnoside 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one Afzelin/Kaempferol 3-o-glucorhamnoside Kaempferol-3-O-α-L-rhamnoside KAEMPFERIN; KAEMPFEROL-3-RHAMNOSIDE 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one KAEMPFEROL 3-O-GLUCORHAMNOSIDE 4H-1-Benzopyran-4-one,3-[(6-deoxy-a-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl) AFZELIN 3-O-α-rhamnosylkaempferol Kaempferin 3-(α-L-Rhamnopyranosyloxy)-5,7,4'-trihydroxyflavone PTEN,MMAC1,Afzelin,Phosphatase and tensin homolog,inhibit,Autophagy,Inhibitor,Bacterial,Mitochondrial Metabolism 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl) kaempferol 3-O-α-L-rhamnopyranoside 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-deoxy-α-L-mannopyranoside 2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl α-L-rhamnopyranoside Afzeloside 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Kaempferol 3-O-Alpha-L-Rhamnoside Kaempferol 3-rhamnoside-RM Trihydroxy-SL0101 Kaempferol 3-rhamnoside KAEMPFEROL 3-O-RHAMNOSIDE KaeMpferin Kaempferol 3-O-α-L-Rhamnoside

Description	Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1. Afzelin improves the survival rate and reduces the serum levels of alanine aminotransferase and pro-inflammatory cytokines in D-galactosamine (GalN)/LPS -treated mice[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> PI3K/Akt/mTOR >> PTEN Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism
References	[1]. Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209.

Hazard Codes	Xi
RIDADR	NONH for all modes of transport