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63527-52-6

63527-52-6 structure
63527-52-6 structure
  • Name: cefotaxime
  • Chemical Name: cefotaxime
  • CAS Number: 63527-52-6
  • Molecular Formula: C16H17N5O7S2
  • Molecular Weight: 455.466
  • Catalog: API Antibiotics Cephalosporin
  • Create Date: 2018-08-11 10:55:54
  • Modify Date: 2024-01-02 15:36:47
  • Cefotaxime, a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4].
Name cefotaxime
Synonyms 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-
Cefotaxime
(6R,7R)-3-(Acetoxymethyl)-7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Zariviz
Cefabol
Cefotaxima acid
EINECS 264-299-1
Cephotaxime
Description Cefotaxime, a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4].
Related Catalog
In Vitro Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6[4].
In Vivo The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens[4]. Animal Model: Female, specific pathogen free, 8-week-old BALB/c mice[4]. Dosage: 30 mg/kg. Administration: IP every 6 h. Result: The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
References

[1]. Hee-Chang Jang, et al. In vivo efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus sepsis. PLoS One. 2014 Jun 30;9(6):e101118.

[2]. Woodfield JC, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185(1):45-9.

[3]. Scholz H, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44(2):142-7.

[4]. Gums JG, et al. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Ann Pharmacother. 2008 Jan;42(1):71-9.
Density 1.8±0.1 g/cm3
Melting Point 162-163℃
Molecular Formula C16H17N5O7S2
Molecular Weight 455.466
Exact Mass 455.056946
PSA 227.05000
LogP 1.20
Index of Refraction 1.779
Storage condition 2-8℃
HS Code 3003201100
HS Code 3003201100

Chemsrc provides CAS#:63527-52-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 63527-52-6 | Chemsrc address: https://m.chemsrc.com/en/baike/946832.html

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