Shanghai Nianxing Industrial Co., Ltd
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: cefotaxime
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63527-52-6

63527-52-6 structure

63527-52-6 structure

Name: cefotaxime
Chemical Name: cefotaxime
CAS Number: 63527-52-6
Molecular Formula: C₁₆H₁₇N₅O₇S₂
Molecular Weight: 455.466
Catalog: API Antibiotics Cephalosporin
Create Date: 2018-08-11 10:55:54
Modify Date: 2026-07-02 11:53:46
Cefotaxime, a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4].

Name	cefotaxime
Synonyms	ACA-JW Cefotaxime 1082-3 (free acid) Zariviz Cefabol (6R)-3-(Acetoxymethyl)-7α-[[(2-amino-4-thiazolyl)[(Z)-methoxyimino]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid Cefotaxime, 10 mM in DMSO Cefotaxima acid Cefotaxime D3Q: What is Cefotaxime D3 Q: What is the CAS Number of Cefotaxime D3 (6R,7R)-3-[(acetyloxy)Methyl]-7-[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetaMido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid 635-6 (((2-amino- 4-thiazolyl)methoxyimino)acetyl)amino)-8-oxo-, (6r-(6alpha,7beta(z) 3-[(Acetyloxy)methyl]-7-[[(2-amino-4-thiazoly)(methoxyimino)acethyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-cboxylic acid(sodium salt) CefotaximeQ: What is Cefotaxime Q: What is the CAS Number of Cefotaxime Q: What is the storage condition of Cefotaxime Q: What e the applications of Cefotaxime (6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid (6R,7R)-3-(Acetoxymethyl)-7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 13C,-Cefotaxime (6R,7R)-3-[(Acetyl-oxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid (6S,7R)-3-(acetoxymethyl)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid sodium 3-(acetyloxymethyl)-7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylate EINECS 264-299-1 Cefotaxime (Cefotaxime Impurity) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R) Ziviz Cefotaxime Acid L (6R,7R)-3-(Acetoxymethyl)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-th Mercaptopurine Impurity 12 （Mercaptopurine Impurity C） Cefotaxime Acid(Cefotaxime) (6R,7R)-3-(acetoxymethyl)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid Cefotaxime acid CRS 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R) (6S,7S)-3-(acetoxymethyl)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid Chotaxime Cephotaxime

Description	Cefotaxime, a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6[4].
In Vivo	The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens[4]. Animal Model: Female, specific pathogen free, 8-week-old BALB/c mice[4]. Dosage: 30 mg/kg. Administration: IP every 6 h. Result: The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
References	[1]. Hee-Chang Jang, et al. In vivo efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus sepsis. PLoS One. 2014 Jun 30;9(6):e101118. [2]. Woodfield JC, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185(1):45-9. [3]. Scholz H, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44(2):142-7. [4]. Gums JG, et al. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Ann Pharmacother. 2008 Jan;42(1):71-9.

Density	1.8±0.1 g/cm3
Melting Point	162-163℃
Molecular Formula	C₁₆H₁₇N₅O₇S₂
Molecular Weight	455.466
Exact Mass	455.056946
PSA	227.05000
LogP	1.20
Index of Refraction	1.779
Storage condition	2-8℃

HS Code	3003201100

Precursor 8
64486-19-7 71754-15-9 80756-85-0 957-68-6
111230-59-2 64485-88-7 65872-39-1 64485-89-8
DownStream 5
80370-57-6 87239-81-4 84957-29-9 84957-30-2
64485-93-4

HS Code	3003201100

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