DC Chemicals Limited
China
Product Name: Cephotaxime
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: cefotaxime
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

63527-52-6

63527-52-6 structure

63527-52-6 structure

Name: cefotaxime
Chemical Name: cefotaxime
CAS Number: 63527-52-6
Molecular Formula: C₁₆H₁₇N₅O₇S₂
Molecular Weight: 455.466
Catalog: API Antibiotics Cephalosporin
Create Date: 2018-08-11 10:55:54
Modify Date: 2024-01-02 15:36:47
Cefotaxime, a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4].

Name	cefotaxime
Synonyms	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)- Cefotaxime (6R,7R)-3-(Acetoxymethyl)-7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Zariviz Cefabol Cefotaxima acid EINECS 264-299-1 Cephotaxime

Description	Cefotaxime, a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6[4].
In Vivo	The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens[4]. Animal Model: Female, specific pathogen free, 8-week-old BALB/c mice[4]. Dosage: 30 mg/kg. Administration: IP every 6 h. Result: The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
References	[1]. Hee-Chang Jang, et al. In vivo efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus sepsis. PLoS One. 2014 Jun 30;9(6):e101118. [2]. Woodfield JC, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185(1):45-9. [3]. Scholz H, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44(2):142-7. [4]. Gums JG, et al. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Ann Pharmacother. 2008 Jan;42(1):71-9.

Density	1.8±0.1 g/cm3
Melting Point	162-163℃
Molecular Formula	C₁₆H₁₇N₅O₇S₂
Molecular Weight	455.466
Exact Mass	455.056946
PSA	227.05000
LogP	1.20
Index of Refraction	1.779
Storage condition	2-8℃

HS Code	3003201100

Precursor 8
64486-19-7 71754-15-9 80756-85-0 957-68-6
111230-59-2 64485-88-7 65872-39-1 64485-89-8
DownStream 5
80370-57-6 87239-81-4 84957-29-9 84957-30-2
64485-93-4

HS Code	3003201100