108605-62-5

108605-62-5 structure

Name: teriflunomide
Chemical Name: 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide
CAS Number: 108605-62-5
Molecular Formula: C₁₂H₉F₃N₂O₂
Molecular Weight: 270.207
Catalog: Biochemical Inhibitor Metabolism Dehydrogenase inhibitor
Create Date: 2018-03-29 08:00:00
Modify Date: 2025-08-20 19:13:27
(E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA)[1].

Name	2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide
Synonyms	2-Butenamide (2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl] Butanenitrile, 2-[hydroxy[[4-(trifluoromethyl)phenyl]amino]methylene]-3-oxo-, (2Z)- (2Z)-2-(Hydroxy{[4-(trifluoromethyl)phenyl]amino}methylene)-3-oxobutanenitrile 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide Teriflunomide 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide

Description	(E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA)[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport