108605-62-5
108605-62-5 structure
- Name: teriflunomide
- Chemical Name: 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide
- CAS Number: 108605-62-5
- Molecular Formula: C12H9F3N2O2
- Molecular Weight: 270.207
- Catalog: Biochemical Inhibitor Metabolism Dehydrogenase inhibitor
- Create Date: 2018-03-29 08:00:00
- Modify Date: 2026-07-02 11:53:52
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(E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA)[1].
| Name | 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide |
|---|---|
| Synonyms |
2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)cro
(2Z)-2-[hydroxy-[4-(trifluoromethyl)anilino]methylidene]-3-oxobutanenitrile (E/Z)-Teriflunomide, 10 mM in DMSO 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl] 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide Teriflunomide Leflunomide Related Compound B (20 mg) (2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide) N-(4-TRIFLUOROMETHYLPHENYL)-2-CYANO-3-HYDROXYCROTOAMIDE 2-CYANO-3-OH-N-(4-TRIFLUOROMETHYLPHENYL) CROTONAMIDE TeriflunoMide, A77 N-(4-TRIFLUOROMETHYLPHENYL)-2-CYANO-3-HYDROXYCROTONAMIDE 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide //BP Su 20 2-CYANO-3-HYDROXY-N-[4-(TRIFLUOROMETHYL)PHENYL]-2-BUTENAMIDE Leflunomide Related Compound B (2-Cyano-3-hydroxy-N-(4''-trifluoromethylphenyl)-crotone amide) 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide/Leflunomide impurityⅡ (E)-2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)-2-butenamide (Z)-2-cyano-3-hydroxy-N-(4-(trifluoroMethyl)phenyl)but-2-enaMide Teriflunomide((E/Z) Mixture) Leflunomide ImpuritⅡ: 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide (2Z)-2-(Hydroxy{[4-(trifluoromethyl)phenyl]amino}methylene)-3-oxobutanenitrile Aids-013145 Leflunomide Related Compound B (E/Z)-Teriflunomide A771726 (Teriflunomide), Active metabolite of leflunomide. Dihydroorotate dehydrogenase inhibitor N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M 2-Butenamide (2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl] 2-Cyano-3OH-N-(4-trifluoromethylphenyl) crotonamide-d4 Aubagio n-(4-trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide 2-cyano-3-hydroxy-n-(4-(trifluoromethyl)phenyl)-2-butenamid (2Z)-2-[hydroxy-[[4-(trifluoromethyl)phenyl]amino]methylidene]-3-oxo-butanenitrile Teriflunomide(Random Configuration) Leflunomide impurityⅡ [2-cyano-3-hydroxy-N-(4’ -trifluoromethylphenyl)-croton e amide Aids013145 2-cyano-3-hydroxy-crotonic acid 4-trifluoro-methyl-anilide IMp. A as Hydrochloride: 4-(TrifluoroMethyl)aniline Hydrochloride rac-A77 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide Leflunomide Related Compound B (10 mg) (2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide) 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Leflunomide impurityⅡ[2-cyano-3-hydroxy-N-(4’-trifluoromethylphenyl)-crotone amide] 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide |
| Description | (E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA)[1]. |
|---|---|
| Related Catalog |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 363.0±42.0 °C at 760 mmHg |
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.207 |
| Flash Point | 173.3±27.9 °C |
| Exact Mass | 270.061615 |
| PSA | 73.12000 |
| LogP | 0.71 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.552 |
| Storage condition | +2C to +8C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |