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136434-34-9

136434-34-9 structure
136434-34-9 structure
  • Name: Duloxetine hydrochloride
  • Chemical Name: (S)-duloxetine hydrochloride
  • CAS Number: 136434-34-9
  • Molecular Formula: C18H20ClNOS
  • Molecular Weight: 333.875
  • Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Inhibitor
  • Create Date: 2018-06-03 08:00:00
  • Modify Date: 2024-01-02 18:31:06
  • Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Target: SNRIDuloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia.The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications.

Name (S)-duloxetine hydrochloride
Synonyms 2-thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride
(S)-(+)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine Hydrochloride
(+)-(S)-N-methyl-g-(1-naphthyloxy)-2-thiophenepropylamine Hydrochloride
(3S)-N-méthyl-3-(naphtalén-1-yloxy)-3-thiophén-2-ylpropan-1-amine chlorhydrate
(S)-Duloxetine hydrochloride
(3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine hydrochloride (1:1)
(S)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine Hydrochloride
duloxetine hcl
2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride (1:1)
(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride
(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine,hydrochloride
(3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1)
(3S)-N-methyl-3-(naphthalen-1-yloxy)-3-thiophen-2-ylpropan-1-amine hydrochloride
(3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride (1:1)
(3S)-N-Methyl-3-(naphthalen-1-yloxy)-3-thiophen-2-ylpropan-1-aminhydrochlorid
Duloxetine hydrochloride
Duloxetine (hydrochloride)
Description Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Target: SNRIDuloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia.The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications.
Related Catalog
References

[1]. Redrobe JP, et al. Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity. Psychopharmacology (Berl). 1998 Jul;138(1):1-8.

[2]. Deecher DC, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318(2):657-65. Epub 2006 May 4.

Boiling Point 466.2ºC at 760 mmHg
Melting Point 118-122ºC
Molecular Formula C18H20ClNOS
Molecular Weight 333.875
Flash Point 235.7ºC
Exact Mass 333.095398
PSA 49.50000
LogP 5.82380
Storage condition -20°C Freezer
Water Solubility H2O: soluble5mg/mL (clear solution, warmed)
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36/37
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
RTECS XN0258000
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%