136434-34-9
136434-34-9 structure
- Name: Duloxetine hydrochloride
- Chemical Name: (S)-duloxetine hydrochloride
- CAS Number: 136434-34-9
- Molecular Formula: C18H20ClNOS
- Molecular Weight: 333.875
- Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Inhibitor
- Create Date: 2018-06-03 08:00:00
- Modify Date: 2026-06-30 12:42:34
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Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Target: SNRIDuloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia.The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications.
| Name | (S)-duloxetine hydrochloride |
|---|---|
| Synonyms |
(γS)-N-methyl-γ-(1-naphthalenyloxy)-2-thiophenropanamine, hydrochloride (1:1)
2-thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride (S)-(+)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine Hydrochloride (gS)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenropanamine Duloxetime (S)-Duloxetine hydrochloride (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine hydrochloride (1:1) (S)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine Hydrochloride duloxetine hcl (S)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine hydrochloride N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aMine hydrochloride (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenropanaMine Hydrochloride Duloxetine (hydrochloride) Duloxetine hydrochloridum Duloxetine hydrochloride (Y0001453) (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine,hydrochloride DuloxetineHydrochloride> N-Methyl-gaMa-(1-naphthalenyloxy)-2-thiophenropa (+)-(S)-N-Methyl-(1-naphthyloxy-d7)-2-thiophenropylamine Duloxetine for system suitability (Y0001454) (RS)Duloxetine HCl (RS)-DULOXEINEHYDROCHLORIDE LY-248686 Duloxetine for system suitability oxetine HydrochL (3S)-N-méthyl-3-(naphtalén-1-yloxy)-3-thiophén-2-ylpropan-1-amine chlorhydrate (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenropylaMine Hydrochloride LY-248686 HCl (S)-DULOXETINE HYDROCHLORIDE;LY-248686 HYDROCHLORIDE Duloxetine Hydrochloride (1.0 mg/mL in Methanol) 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride (1:1) N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenropanamine (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride (1:1) DuL Duloxetine HCl and intermediates methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2- yl)propyl]amine hydrochloride Duloxetine hydrochloride, (HPLC) S-Duloxetine HCl (S)-Duloxetine hydrochloride(CyMbalta) (S)-N-METHYL-3-(NAPHTHALEN-1-YLOXY)-3-(THIOPHEN-2-YL)PROPAN-1-AMINE HCL (S)-N-Methyl-(1-naphthalenyloxy)-2-thiophenropanamine (+)-(S)-N-methyl-g-(1-naphthyloxy)-2-thiophenepropylamine Hydrochloride Duloxetine hydrochloride solution (+)-(S)-N-Methyl-g-(1-naphthyloxy-d7)-2-thiophenropylamine (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1) (S)-N-Methyl-(1-naphthalenyloxy-d7)-2-thiophenropanamine (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aMine hydrochloride DULOXETINE HCL (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-thiophen-2-ylpropan-1-amine hydrochloride (+)-(S)-N-Methyl-(1-naphthyloxy)-2-thiophenropylamine Duloxetine hydrochloride //BP (S)-DULOXETINE HYDROCHLORIDE Duloxetine HydrochlorideQ: What is Duloxetine Hydrochloride Q: What is the CAS Number of Duloxetine Hydrochloride Q: What e the applications of Duloxetine Hydrochloride Methanol（ Test Duloxetine HCl, 1.0 mg/mL as free base） Duloxetine for system suitability CRS (+)-(S)-N-Methyl-g-(1-naphthyloxy)-2-thiophenropylamine Duloxetine hydrochloride CRS DULOXETINE HYDROCHLORIDE (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride (gS)-N-Methyl-g-(1-naphthalenyloxy-d7)-2-thiophenropanamine N-methyl-gamma-(1-naphthalenyloxy)-2-thiophenropanamine, hydrochloride (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenropylamine LY-248686 hydrochloride (S)-N,N-DiMethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aMine hydrochloride Duloxetine HCl (LY-248686 HCl) (+)-(S)-n-methyl-g-(1-naphthyloxy)-2-thiophenropylamine, hydrochloride/duloxetinehcl (3S)-N-Methyl-3-(naphthalen-1-yloxy)-3-thiophen-2-ylpropan-1-aminhydrochlorid DULOXETINE: DULOXETINE HYDROCHLORIDE |
| Description | Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Target: SNRIDuloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia.The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications. |
|---|---|
| Related Catalog | |
| References |
| Boiling Point | 466.2ºC at 760 mmHg |
|---|---|
| Melting Point | 118-122ºC |
| Molecular Formula | C18H20ClNOS |
| Molecular Weight | 333.875 |
| Flash Point | 235.7ºC |
| Exact Mass | 333.095398 |
| PSA | 49.50000 |
| LogP | 5.82380 |
| Storage condition | -20°C Freezer |
| Water Solubility | H2O: soluble5mg/mL (clear solution, warmed) |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36/37 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| RTECS | XN0258000 |
| HS Code | 2934999090 |
| Precursor 6 | |
|---|---|
| DownStream 3 | |
![4-[3-(Methylamino)-1-(2-thienyl)propyl]-1-naphthalenol structure](https://image.chemsrc.com/caspic/202/949095-98-1.png)
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |