95975-55-6
95975-55-6 structure
- Name: Guggulsterone E&Z
- Chemical Name: (Z)-Guggulsterone
- CAS Number: 95975-55-6
- Molecular Formula: C21H28O2
- Molecular Weight: 312.446
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-08-20 08:12:52
- Modify Date: 2025-08-27 10:43:20
-
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively[2].
| Name | (Z)-Guggulsterone |
|---|---|
| Synonyms |
Z-Guggulsterone
Cis-Guggulsterone Neuropeptide W-23 (human) CIS GUGGULSTERONE GUGGULSTERONE Z(P) GUGGULSTERONE, (Z)- E-guggulsterone Z-Gugglesterone GUGGULSTERONE Z (4,17(20)t)-Pregnadien-3,16-dion Guggulsterone Z (25 mg) Guggulsterone GUGGULESTERONE Z Pregna-4,17(20)-diene-3,16-dione, (17Z)- MFCD01310757 (17Z)-Pregna-4,17-diene-3,16-dione 4,17(20)-Z-pregnadiene-3,16-dione GUGGULSTERONE (Z FORM) GUGULSTERONE UNII:6CST3U34GN Pregna-4,17-diene-3,16-dione, (17Z)- Z-Guggulsteron |
| Description | Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively[2]. |
|---|---|
| Related Catalog | |
| Target |
JNK Akt Caspase |
| In Vitro | Guggulsterone (0.5-20 μM; 24 hours) suppresses TREM-1, TLR4 and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS[2]. Western Blot Analysis[1] Cell Line: RAW 264.7 murine macrophage cells Concentration: 0.5, 5, 10, 20 μM Incubation Time: 24 hours Result: Suppressed TREM-1, TLR4, and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS. |
| In Vivo | Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis[2]. Animal Model: Wild-type mice with TNBS-induced colitis[2] Dosage: 100 mg/kg Administration: Orally; once per day; for 8 days Result: Improved the survival rates of wild-type mice with TNBS-induced colitis. |
| References |
[1]. Shishodia S, et al. Guggulsterone for Chemoprevention of Cancer. Curr Pharm Des. 2016;22(3):294-306. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 463.3±45.0 °C at 760 mmHg |
| Molecular Formula | C21H28O2 |
| Molecular Weight | 312.446 |
| Flash Point | 172.3±25.7 °C |
| Exact Mass | 312.208923 |
| PSA | 34.14000 |
| LogP | 3.65 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.557 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: 5 mg/mL |