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6601-66-7

6601-66-7 structure
6601-66-7 structure
  • Name: 6-Demethoxytangeretin
  • Chemical Name: 5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
  • CAS Number: 6601-66-7
  • Molecular Formula: C19H18O6
  • Molecular Weight: 342.343
  • Catalog: Natural product Flavonoids
  • Create Date: 2018-07-04 14:50:40
  • Modify Date: 2025-08-25 14:00:17
  • 6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].
Name 5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
Synonyms 6-Demethoxytangeretin
4',5,7,8-Tetramethoxyflavone
5,7,8-Trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-(4-methoxyphenyl)-
5,7,8,4'-tetramethoxyflavone
UNII-2U2U884D0P
6-Demethoxytangeritin
Tetra-O-methylisoscutellarein
tetramethyl-o-isoscutellarein
Description 6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].
Related Catalog
References

[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5.

[2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.
Density 1.243±0.06 g/cm3
Boiling Point 536.9±50.0 °C at 760 mmHg
Melting Point 216-217 ºC
Molecular Formula C19H18O6
Molecular Weight 342.343
Flash Point 237.5±30.2 °C
Exact Mass 342.110352
PSA 67.13000
LogP 3.06
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.575
Storage condition 2-8℃
Water Solubility Practically insoluble (0.027 g/L) (25 ºC)
Hazard Codes Xi
HS Code 2914509090
HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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