6-Demethoxytangeretin

Modify Date: 2024-01-09 18:02:33

6-Demethoxytangeretin structure	Common Name	6-Demethoxytangeretin
	CAS Number	6601-66-7	Molecular Weight	342.343
	Density	1.243±0.06 g/cm3	Boiling Point	536.9±50.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₁₈O₆	Melting Point	216-217 ºC
	MSDS	N/A	Flash Point	237.5±30.2 °C

Use of 6-Demethoxytangeretin

6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].

Name	5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
Synonym	More Synonyms

Description	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
References	[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. [2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

References

[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5.

[2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.

Density	1.243±0.06 g/cm3
Boiling Point	536.9±50.0 °C at 760 mmHg
Melting Point	216-217 ºC
Molecular Formula	C₁₉H₁₈O₆
Molecular Weight	342.343
Flash Point	237.5±30.2 °C
Exact Mass	342.110352
PSA	67.13000
LogP	3.06
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.575
Storage condition	2-8℃
Water Solubility	Practically insoluble (0.027 g/L) (25 ºC)

Hazard Codes	Xi
HS Code	2914509090

Precursor 10
CAS#:6601-67-8 4'-benzyloxy-5,... CAS#:1486-51-7 4-(Benzyloxy)be... CAS#:7507-98-4 1-(2-hydroxy-3,... CAS#:56595-80-3 2-hydroxy-4'-be...
CAS#:56595-79-0 2-(4'-benzyloxy... CAS#:794-94-5 Benzoic acid,4-... CAS#:73909-61-2 4'-hydroxy-5,7,... CAS#:57096-03-4 5-hydroxy-7,8-d...
CAS#:74-88-4 methyl iodide CAS#:6608-33-9 4',5-dihydroxy-...
DownStream 3
CAS#:529-53-3 Scutellarein CAS#:54917-70-3 [4-(5,7,8-triac... CAS#:41440-05-5 isoscutellarein

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%