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32502-63-9

32502-63-9 structure
32502-63-9 structure
  • Name: 3-Phenyltoxoflavin
  • Chemical Name: 1,6-dimethyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
  • CAS Number: 32502-63-9
  • Molecular Formula: C13H11N5O2
  • Molecular Weight: 269.25900
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
  • Create Date: 2017-01-10 04:37:57
  • Modify Date: 2024-01-20 21:32:37
  • 3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].
Name 1,6-dimethyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
Synonyms 3-Phenyl-toxoflavin
Description 3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].
Related Catalog
Target

HSP90:585 nM (Kd)
In Vitro 3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM[1]. 3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner[1].
References

[1]. Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3(10):645-54.

[2]. Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9(3):348-58.
Molecular Formula C13H11N5O2
Molecular Weight 269.25900
Exact Mass 269.09100
PSA 82.67000
LogP 0.08920
Hazard Codes Xi
42285-76-7 structure

42285-76-7
77-78-1 structure

77-78-1

~91%

32502-63-9 structure

32502-63-9
Literature: Nagamatsu, Tomohisa; Yamasaki, Hirofumi Heterocycles, 1997 , vol. 45, # 4 p. 643 - 650 Title/Abstract Full Text View citing articles Show Details Nagamatsu, Tomohisa; Yamasaki, Hirofumi Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 2 p. 130 - 137
32502-53-7 structure

32502-53-7

~51%

32502-63-9 structure

32502-63-9
Literature: Raoof, Ali; Depledge, Paul; Hamilton, Niall M.; Hamilton, Nicola S.; Hitchin, James R.; Hopkins, Gemma V.; Jordan, Allan M.; Maguire, Laura A.; McGonagle, Alison E.; Mould, Daniel P.; Rushbrooke, Mathew; Small, Helen F.; Smith, Kate M.; Thomson, Graeme J.; Turlais, Fabrice; Waddell, Ian D.; Waszkowycz, Bohdan; Watson, Amanda J.; Ogilvie, Donald J. Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6352 - 6370
42285-76-7 structure

42285-76-7

~%

32502-63-9 structure

32502-63-9
Literature: Nagamatsu, Tomohisa; Yamasaki, Hirofumi Heterocycles, 1997 , vol. 45, # 4 p. 643 - 650
164520-16-5 structure

164520-16-5

~%

32502-63-9 structure

32502-63-9
Literature: Nagamatsu, Tomohisa; Yamasaki, Hirofumi Heterocycles, 1997 , vol. 45, # 4 p. 643 - 650
164520-07-4 structure

164520-07-4

~%

32502-63-9 structure

32502-63-9
Literature: Nagamatsu, Tomohisa; Yamasaki, Hirofumi Heterocycles, 1997 , vol. 45, # 4 p. 643 - 650
164520-14-3 structure

164520-14-3

~%

32502-63-9 structure

32502-63-9
Literature: Nagamatsu, Tomohisa; Yamasaki, Hirofumi Heterocycles, 1997 , vol. 45, # 4 p. 643 - 650
4318-56-3 structure

4318-56-3

~%

32502-63-9 structure

32502-63-9
Literature: Raoof, Ali; Depledge, Paul; Hamilton, Niall M.; Hamilton, Nicola S.; Hitchin, James R.; Hopkins, Gemma V.; Jordan, Allan M.; Maguire, Laura A.; McGonagle, Alison E.; Mould, Daniel P.; Rushbrooke, Mathew; Small, Helen F.; Smith, Kate M.; Thomson, Graeme J.; Turlais, Fabrice; Waddell, Ian D.; Waszkowycz, Bohdan; Watson, Amanda J.; Ogilvie, Donald J. Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6352 - 6370
100-52-7 structure

100-52-7
42747-84-2 structure

42747-84-2

~%

32502-63-9 structure

32502-63-9
Literature: Raoof, Ali; Depledge, Paul; Hamilton, Niall M.; Hamilton, Nicola S.; Hitchin, James R.; Hopkins, Gemma V.; Jordan, Allan M.; Maguire, Laura A.; McGonagle, Alison E.; Mould, Daniel P.; Rushbrooke, Mathew; Small, Helen F.; Smith, Kate M.; Thomson, Graeme J.; Turlais, Fabrice; Waddell, Ian D.; Waszkowycz, Bohdan; Watson, Amanda J.; Ogilvie, Donald J. Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6352 - 6370

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