SPD304 dihydrochloride

Modify Date: 2024-01-30 17:45:11

SPD304 dihydrochloride structure	Common Name	SPD304 dihydrochloride
	CAS Number	1049741-03-8	Molecular Weight	620.532
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₄Cl₂F₃N₃O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of SPD304 dihydrochloride

SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2].

Name	TNF-α Inhibitor
Synonym	More Synonyms

Description	SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	IC50: 22 µM (TNFα)[1].
In Vitro	SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p−RIP3 1.4−fold compared to GA alone, and promotes caspase 8 activation[4].
In Vivo	SPD304 cannot be used in vivo due to its high toxicity[3].
References	[1]. Molly M. He, et al. Small-Molecule Inhibition of TNF-α. Science 11 Nov 2005. [2]. Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim). 2014 Nov;347(11):798-805. [3]. Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7(1):3424. [4]. Gallic acid induces necroptosis via TNF-α signaling pathway in activated hepatic stellate cells. Chang YJ, et al. PLoS One. 2015 Mar 27;10(3):e0120713.

Molecular Formula	C₃₂H₃₄Cl₂F₃N₃O₂
Molecular Weight	620.532
Exact Mass	619.197998
Appearance of Characters	white Solid
Storage condition	Store at -20° C
Water Solubility	Soluble in DMSO (10 mg/ml).

Hazard Codes	Xi

4H-1-Benzopyran-4-one, 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-, hydrochloride (1:2)

SPD00000304

MFCD09265259

6,7-Dimethyl-3-[(methyl{2-[methyl({1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl}methyl)amino]ethyl}amino)methyl]-4H-chromen-4-one dihydrochloride

SPD304

6,7-Dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-(4H-1-Benzopyran-4-one dihydrochloride

DC Chemicals Limited
China
Product Name: SPD304 dihydrochloride
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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