Filipin complex

Modify Date: 2024-01-02 13:26:10

Filipin complex structure	Common Name	Filipin complex
	CAS Number	11078-21-0	Molecular Weight	654.82800
	Density	1.161 g/cm3	Boiling Point	913.9ºC at 760 mmHg
	Molecular Formula	C₃₅H₅₈O₁₁(forFilipinIII)	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	279.3ºC
	Symbol	GHS07	Signal Word	Warning

Use of Filipin complex

Filipin, produced as a mixture of related compounds known as the filipin complex (filipins I-IV) in nature[1], is a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure. Filipin III is the major component of Filipin[2].

Name	Filipin complex from Streptomyces filipinensis
Synonym	More Synonyms

Description	Filipin, produced as a mixture of related compounds known as the filipin complex (filipins I-IV) in nature[1], is a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure. Filipin III is the major component of Filipin[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Kelly PM, et al. Separation of the filipin complex by gradient-elution high performance liquid chromatography. J Antibiot (Tokyo). 1985 Apr;38(4):485-9. [2]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Anti-infection >> Fungal

References

[1]. Kelly PM, et al. Separation of the filipin complex by gradient-elution high performance liquid chromatography. J Antibiot (Tokyo). 1985 Apr;38(4):485-9.

[2]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

Density	1.161 g/cm3
Boiling Point	913.9ºC at 760 mmHg
Molecular Formula	C₃₅H₅₈O₁₁(forFilipinIII)
Molecular Weight	654.82800
Flash Point	279.3ºC
Exact Mass	654.39800
PSA	208.37000
LogP	1.88800
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK4400000

CHEMICAL NAME :: Filipin

CAS REGISTRY NUMBER :: 11078-21-0

LAST UPDATED :: 198211

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,215,1980

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xn: Harmful;Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

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(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,1 0,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethylo xacyclooctacosa-17,19,21,23,25-pentaen-2-one

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: FILIPIN COMPLEX
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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