Propargyl-PEG6-NH2

Modify Date: 2024-06-27 12:05:37

Propargyl-PEG6-NH2 Structure
Propargyl-PEG6-NH2 structure
Common Name Propargyl-PEG6-NH2
CAS Number 1198080-04-4 Molecular Weight 319.394
Density 1.1±0.1 g/cm3 Boiling Point 401.8±40.0 °C at 760 mmHg
Molecular Formula C15H29NO6 Melting Point N/A
MSDS N/A Flash Point 190.0±21.0 °C

 Use of Propargyl-PEG6-NH2


Propargyl-PEG6-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

 Names

Name 3,6,9,12,15,18-Hexaoxahenicos-20-yn-1-amine
Synonym More Synonyms

 Propargyl-PEG6-NH2 Biological Activity

Description Propargyl-PEG6-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 401.8±40.0 °C at 760 mmHg
Molecular Formula C15H29NO6
Molecular Weight 319.394
Flash Point 190.0±21.0 °C
Exact Mass 319.199493
LogP -1.89
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.465

 Synonyms

3,6,9,12,15,18-Hexaoxaheneicos-20-yn-1-amine
3,6,9,12,15,18-Hexaoxahenicos-20-yn-1-amine
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