Fipronil

Modify Date: 2024-01-02 07:27:33

Fipronil Structure
Fipronil structure
Common Name Fipronil
CAS Number 120068-37-3 Molecular Weight 437.148
Density 1.9±0.1 g/cm3 Boiling Point 510.1±50.0 °C at 760 mmHg
Molecular Formula C12H4Cl2F6N4OS Melting Point 200-201°C
MSDS Chinese USA Flash Point 262.3±30.1 °C
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

 Use of Fipronil


Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC500s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

 Names

Name fipronil
Synonym More Synonyms

 Fipronil Biological Activity

Description Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC500s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.
Related Catalog

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 510.1±50.0 °C at 760 mmHg
Melting Point 200-201°C
Molecular Formula C12H4Cl2F6N4OS
Molecular Weight 437.148
Flash Point 262.3±30.1 °C
Exact Mass 435.938690
PSA 103.91000
LogP 4.76
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.618
Storage condition 0-6°C

 Safety Information

Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H301 + H311 + H331-H319-H372-H410
Precautionary Statements P261-P273-P280-P301 + P310 + P330-P302 + P352 + P312-P304 + P340 + P312
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes N: Dangerous for the environment;T: Toxic;
Risk Phrases R23/24/25
Safety Phrases S26-S36/37/39-S45-S60-S61
RIDADR 2588
WGK Germany 3.0
RTECS UQ4430250
Packaging Group III
Hazard Class 6.1(b)

 Synthetic Route

 Articles27

More Articles
Superficially porous particles vs. fully porous particles for bonded high performance liquid chromatographic chiral stationary phases: isopropyl cyclofructan 6.

J. Chromatogr. A. 1363 , 89-95, (2014)

This work reports a comparison of HPLC separations of enantiomers with chiral stationary phases (CSPs) prepared by chemically bonding cyclofructan-6, functionalized with isopropyl carbamate groups on ...

Persistence and effect of processing on reduction of fipronil and its metabolites in chilli pepper (Capsicum annum L.) fruits.

Environ. Monit. Assess. 186(9) , 5429-37, (2014)

A single laboratory UPLC-MS/MS method was developed and validated for the estimation of fipronil and its metabolites in fresh and dry chilli pepper fruits. Dissipation of fipronil on chilli fruits was...

Acute toxicity and sublethal effects of fipronil on detoxification enzymes in juvenile zebrafish (Danio rerio)

Pestic. Biochem. Physiol. 115 , 9-14, (2014)

The acute toxicity of fipronil and its sublethal effects on detoxification enzymes (carboxylesterases (CarEs), glutathione S-transferases (GSTs), and 7-ethoxycoumarin O-deethylase (ECOD)) in zebrafish...

 Synonyms

Fipronil (JAN)
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethanesulfinyl)-1H-pyrazole-3-carbonitrile
Fluocyanobenpyrazole
EINECS 424-610-5
5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile
1H-Pyrazole-3-carbonitrile, 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-
5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole
(±)-Fipronil
5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethyl)sulfinyl-1H-pyrazole-3-carbonitrile
(±)-5-Amino-1-(2,6-dichloro-a,a,a-trifluoro-p-tolyl)-4-trifluoromethylsulfinylpyrazole-3-carbonitrile
RM 1601
MFCD00867812
Termidor
T5NNJ AR BG FG DXFFF& CCN DSO&XFFF EZ &&(RS) Form
5-Amino-1-(2,6-dichloro-α,α,α-trifluoro-p-tolyl)-4-[(trifluoromethyl)sulfinyl]pyrazole-3-carbonitrile
Fipronil
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