Thalidomide-5-OH
Thalidomide-5-OH structure
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Common Name | Thalidomide-5-OH | ||
|---|---|---|---|---|
| CAS Number | 64567-60-8 | Molecular Weight | 274.22900 | |
| Density | 1.611g/cm3 | Boiling Point | 600ºC at 760mmHg | |
| Molecular Formula | C13H10N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 316.7ºC | |
Use of Thalidomide-5-OHThalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1]. |
| Name | 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindole-1,3-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1]. |
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| Related Catalog | |
| Target |
Cereblon |
| References |
| Density | 1.611g/cm3 |
|---|---|
| Boiling Point | 600ºC at 760mmHg |
| Molecular Formula | C13H10N2O5 |
| Molecular Weight | 274.22900 |
| Flash Point | 316.7ºC |
| Exact Mass | 274.05900 |
| PSA | 107.27000 |
| LogP | 0.00720 |
| Index of Refraction | 1.679 |
| InChIKey | LJBQRRQTZUJWRC-UHFFFAOYSA-N |
| SMILES | O=C1CCC(N2C(=O)c3ccc(O)cc3C2=O)C(=O)N1 |
| Hazard Codes | Xi |
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~59%
Thalidomide-5-OH CAS#:64567-60-8 |
| Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714 |
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Thalidomide-5-OH CAS#:64567-60-8 |
| Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714 |
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Thalidomide-5-OH CAS#:64567-60-8 |
| Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714 |
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Thalidomide-5-OH CAS#:64567-60-8 |
| Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714 |
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~%
Thalidomide-5-OH CAS#:64567-60-8 |
| Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714 |
|
~%
Thalidomide-5-OH CAS#:64567-60-8 |
| Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714 |
|
~%
Thalidomide-5-OH CAS#:64567-60-8 |
| Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714 |
| 5-Hydroxythalidomide |