Thalidomide-5-OH

Modify Date: 2025-08-26 12:41:11

Thalidomide-5-OH Structure
Thalidomide-5-OH structure
 Common Name Thalidomide-5-OH
CAS Number 64567-60-8 Molecular Weight 274.22900
Density 1.611g/cm3 Boiling Point 600ºC at 760mmHg
Molecular Formula C13H10N2O5 Melting Point N/A
MSDS N/A Flash Point 316.7ºC

 Use of Thalidomide-5-OH


Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

 Names

Name 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindole-1,3-dione
Synonym More Synonyms

 Thalidomide-5-OH Biological Activity

Description Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog
Target

Cereblon

References

[1]. Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.

 Chemical & Physical Properties

Density 1.611g/cm3
Boiling Point 600ºC at 760mmHg
Molecular Formula C13H10N2O5
Molecular Weight 274.22900
Flash Point 316.7ºC
Exact Mass 274.05900
PSA 107.27000
LogP 0.00720
Index of Refraction 1.679

 Safety Information

Hazard Codes Xi

 Synthetic Route

5-(Benzyloxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione structure

5-(Benzyloxy)-2...

CAS#:94464-27-4

~59%

Thalidomide-5-OH Structure

Thalidomide-5-OH

CAS#:64567-60-8

Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
5-(Benzyloxy)isobenzofuran-1,3-dione structure

5-(Benzyloxy)is...

CAS#:5840-65-3

~%

Thalidomide-5-OH Structure

Thalidomide-5-OH

CAS#:64567-60-8

Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
3-aminopiperidine-2,6-dione hydrobromide structure

3-aminopiperidi...

CAS#:90802-45-2

~%

Thalidomide-5-OH Structure

Thalidomide-5-OH

CAS#:64567-60-8

Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
4-Hydroxyphthalic acid structure

4-Hydroxyphthal...

CAS#:610-35-5

~%

Thalidomide-5-OH Structure

Thalidomide-5-OH

CAS#:64567-60-8

Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
(S)-5-AMINO-2-(TERT-BUTOXYCARBONYLAMINO)-5-OXOPENTANOIC ACID structure

(S)-5-AMINO-2-(...

CAS#:85535-45-1

~%

Thalidomide-5-OH Structure

Thalidomide-5-OH

CAS#:64567-60-8

Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
4-(benzyloxy)benzene-1,2-dicarboxylic acid structure

4-(benzyloxy)be...

CAS#:5840-66-4

~%

Thalidomide-5-OH Structure

Thalidomide-5-OH

CAS#:64567-60-8

Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
3-Boc-amino-2,6-dioxopiperidine structure

3-Boc-amino-2,6...

CAS#:31140-42-8

~%

Thalidomide-5-OH Structure

Thalidomide-5-OH

CAS#:64567-60-8

Literature: Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714

 Synonyms

5-Hydroxythalidomide
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