DIBROMOCHLOROMETHANE

Modify Date: 2024-01-02 09:48:36

DIBROMOCHLOROMETHANE Structure
DIBROMOCHLOROMETHANE structure
Common Name DIBROMOCHLOROMETHANE
CAS Number 124-48-1 Molecular Weight 208.280
Density 2.5±0.1 g/cm3 Boiling Point 117.1±8.0 °C at 760 mmHg
Molecular Formula CHBr2Cl Melting Point −22 °C(lit.)
MSDS Chinese USA Flash Point 19.8±8.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name chlorodibromomethane
Synonym More Synonyms

 Chemical & Physical Properties

Density 2.5±0.1 g/cm3
Boiling Point 117.1±8.0 °C at 760 mmHg
Melting Point −22 °C(lit.)
Molecular Formula CHBr2Cl
Molecular Weight 208.280
Flash Point 19.8±8.5 °C
Exact Mass 205.813339
LogP 2.20
Vapour Pressure 21.0±0.2 mmHg at 25°C
Index of Refraction 1.562

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PA6360000
CHEMICAL NAME :
Methane, chlorodibromo-
CAS REGISTRY NUMBER :
124-48-1
BEILSTEIN REFERENCE NO. :
1731046
LAST UPDATED :
199710
DATA ITEMS CITED :
27
MOLECULAR FORMULA :
C-H-Br2-Cl
MOLECULAR WEIGHT :
208.29
WISWESSER LINE NOTATION :
GYEE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - tremor
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Liver - fatty liver degeneration Blood - hemorrhage
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14 gm/kg/14D-I
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg/4W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8568 mg/kg/9W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16250 mg/kg/13W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3500 mg/kg/14D-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
52500 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
720 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 369,243,1996 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,243,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,243,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,243,1991

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful;
Risk Phrases R22;R36/37/38;R40
Safety Phrases S45-S36/37/39-S26-S36/37
RIDADR 2810
WGK Germany 3
RTECS PA6360000
Packaging Group III
HS Code 2903799090

 Synthetic Route

 Customs

HS Code 2903799090
Summary 2903799090 halogenated derivatives of acyclic hydrocarbons containing two or more different halogens。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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 Synonyms

Methane, dibromochloro-
1,2-Dibromochloromethane
Chlorodibromomethane, in Certan bottle
MFCD00000820
Dibromo(chloro)methane
chlorodibromomethane
EINECS 204-704-0
DIBROMOCHLOROMETHANE
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