BROMODICHLOROMETHANE

Modify Date: 2026-06-30 21:51:25

BROMODICHLOROMETHANE structure	Common Name	BROMODICHLOROMETHANE
	CAS Number	75-27-4	Molecular Weight	163.82900
	Density	1.98 g/mL at 25 °C(lit.)	Boiling Point	87 °C(lit.)
	Molecular Formula	CHBrCl₂	Melting Point	−55 °C(lit.)
	MSDS	Chinese USA	Flash Point	87-89°C
	Symbol	GHS05, GHS07, GHS08	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	bromodichloromethane
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.98 g/mL at 25 °C(lit.)
Boiling Point	87 °C(lit.)
Melting Point	−55 °C(lit.)
Molecular Formula	CHBrCl₂
Molecular Weight	163.82900
Flash Point	87-89°C
Exact Mass	161.86400
LogP	2.14250
Index of Refraction	n20/D 1.497(lit.)
InChIKey	FMWLUWPQPKEARP-UHFFFAOYSA-N
SMILES	ClC(Cl)Br

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

BROMODICHLOROMETHANE MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA5310000

CHEMICAL NAME :: Methane, bromodichloro-

CAS REGISTRY NUMBER :: 75-27-4

BEILSTEIN REFERENCE NO. :: 1697005

LAST UPDATED :: 199806

DATA ITEMS CITED :: 37

MOLECULAR FORMULA :: C-H-Br-Cl2

MOLECULAR WEIGHT :: 163.83

WISWESSER LINE NOTATION :: GYGE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Liver - fatty liver degeneration Blood - hemorrhage

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg/5D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5670 mg/kg/4W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19500 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9828 mg/kg/9W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20075 mg/kg/2Y-C

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - other changes Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg/14D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg/5D-I

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25500 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25500 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 51 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38250 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 750 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 umol/L

REFERENCE :: TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- Volume(issue)/page/year: 13,205,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,179,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,179,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,179,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5772 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3266 (estimated) No. of Female Employees: 502 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS05, GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H315-H318-H335-H351
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R40
Safety Phrases	S26-S36/39-S45-S36/37-S16-S36/37/39
RIDADR	2810
WGK Germany	3
RTECS	PA5310000
Packaging Group	III
Hazard Class	6.1

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:67-66-3 Chloroform CAS#:75-09-2 Dichloromethane CAS#:463-82-1 2,2-dimethylpropane CAS#:74-96-4 Bromoethane
CAS#:2648-61-5 Ethanone,2,2-di... CAS#:75-25-2 Bromoform CAS#:34557-54-5 methane CAS#:82621-77-0 2,2-dimethyl-N-...
CAS#:75-62-7 Bromotrichlorom...
DownStream 10
CAS#:7647-15-6 Sodium bromide CAS#:7647-14-5 sodium chloride CAS#:1605-72-7 dichlorocarbene CAS#:2108-20-5 chloromethylene...
CAS#:75-09-2 Dichloromethane CAS#:124-48-1 DIBROMOCHLOROMETHANE CAS#:18684-82-7 Z-1-chloro-4-(2... CAS#:3510-48-3 Benzaldehyde,4-...
CAS#:66482-29-9 (E)-β-bromo-p-c... CAS#:3474-12-2 dichloromethane

This table lists relevant public references with title, journal and publication metadata for this compound.

Use of urinary trichloroacetic acid as an exposure biomarker of disinfection by-products in cancer studies.

Environ. Res. 135 , 276-84, (2014)

Urinary trichloroacetic acid (TCAA) has been proposed as a valid exposure biomarker for ingested disinfection by-products (DBP) for reproductive studies. However, it has never been used in epidemiolog...

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

Eur. J. Med. Chem. 44 , 3658-64, (2009)

A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

Comparing a silver-impregnated activated carbon with an unmodified activated carbon for disinfection by-product minimisation and precursor removal.

Sci. Total Environ. 542 , 672-84, (2015)

During disinfection, bromide, iodide and natural organic matter (NOM) in source waters can lead to the formation of brominated and/or iodinated disinfection by-products (DBPs), which are often more to...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Total 216, Current Page 1 of 22

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

MFCD00000824

EINECS 200-856-7

BROMODICHLOROMETHANE

bromo(dichloro)methane

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the safety information for bromodichloromethane?

A: Safety information for bromodichloromethane: S26-S36/39-S45-S36/37-S16-S36/37/39.

Q: What is the boiling point of bromodichloromethane?

A: Boiling point of bromodichloromethane is 87 °C(lit.).

Q: What are the downstream products of bromodichloromethane?

A: Related downstream products(CAS) of bromodichloromethane: 7647-15-6;7647-14-5;1605-72-7;2108-20-5;75-09-2;124-48-1;18684-82-7;3510-48-3;66482-29-9;3474-12-2.

Q: What English synonyms does bromodichloromethane have?

A: English synonyms of bromodichloromethane: MFCD00000824, EINECS 200-856-7, BROMODICHLOROMETHANE, bromo(dichloro)methane.

Q: What is the English name of bromodichloromethane?

A: The English name of bromodichloromethane is bromodichloromethane.

Q: What is the SMILES notation of bromodichloromethane?

A: SMILES notation of bromodichloromethane is ClC(Cl)Br.

Q: What is the InChIKey of bromodichloromethane?

A: InChIKey of bromodichloromethane is FMWLUWPQPKEARP-UHFFFAOYSA-N.

Q: What is the LogP of bromodichloromethane?

A: LogP of bromodichloromethane is 2.14250.

Q: What is the CAS number of bromodichloromethane?

A: CAS number of bromodichloromethane is 75-27-4.

Q: What is the molecular formula of bromodichloromethane?

A: Molecular formula of bromodichloromethane is CHBrCl2.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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