BCI

Modify Date: 2024-01-11 10:01:51

BCI Structure
BCI structure
Common Name BCI
CAS Number 1245792-51-1 Molecular Weight 317.424
Density 1.2±0.1 g/cm3 Boiling Point 484.6±45.0 °C at 760 mmHg
Molecular Formula C22H23NO Melting Point N/A
MSDS N/A Flash Point 161.3±28.9 °C

 Use of BCI


BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5[1].

 Names

Name (2E)-2-Benzylidene-3-(cyclohexylamino)-1-indanone
Synonym More Synonyms

 BCI Biological Activity

Description BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5[1].
Related Catalog
References

[1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 484.6±45.0 °C at 760 mmHg
Molecular Formula C22H23NO
Molecular Weight 317.424
Flash Point 161.3±28.9 °C
Exact Mass 317.177979
LogP 5.65
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.625

 Safety Information

Hazard Codes Xi

 Synonyms

(2E)-2-Benzylidene-3-(cyclohexylamino)-1-indanone
1H-Inden-1-one, 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-, (2E)-
MFCD20232928
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