CU-CPT-8m

Modify Date: 2024-01-17 09:40:08

CU-CPT-8m Structure
CU-CPT-8m structure
 Common Name CU-CPT-8m
CAS Number 125079-83-6 Molecular Weight 252.27
Density N/A Boiling Point N/A
Molecular Formula C14H12N4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CU-CPT-8m


CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM.

 Names

Name CU-CPT-8m
Synonym More Synonyms

 CU-CPT-8m Biological Activity

Description CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM.
Related Catalog
Target

TLR8:67 nM (IC50)

In Vitro CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67±10 nM and negligible cytotoxicity. The Kd value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC50 of 90±10 nM, which is in good agreement with its IC50 value determined in HEK-Blue TLR8 cells[1].
References

[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.

 Chemical & Physical Properties

Molecular Formula C14H12N4O
Molecular Weight 252.27
Storage condition 2-8℃

 Synonyms

CPD1578
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