MKC-1
Modify Date: 2025-08-25 19:25:57
MKC-1 structure
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Common Name | MKC-1 | ||
|---|---|---|---|---|
| CAS Number | 125313-92-0 | Molecular Weight | 400.38700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H16N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MKC-1MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family[1][2][3]. |
| Name | 3-(1-methylindol-3-yl)-4-(1-methyl-6-nitroindol-3-yl)pyrrole-2,5-dione |
|---|---|
| Synonym | More Synonyms |
| Description | MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family[1][2][3]. |
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| Related Catalog | |
| In Vivo | MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors[3]. |
| References |
| Molecular Formula | C22H16N4O4 |
|---|---|
| Molecular Weight | 400.38700 |
| Exact Mass | 400.11700 |
| PSA | 105.34000 |
| LogP | 3.94450 |
| InChIKey | OVSKGTONMLKNPZ-UHFFFAOYSA-N |
| SMILES | Cn1cc(C2=C(c3cn(C)c4cc([N+](=O)[O-])ccc34)C(=O)NC2=O)c2ccccc21 |
| MKC-1 |
| UNII-DNZ11VPY7Q |
| Bisindolylmaleimide deriv. 44 |
| 3-(1-methyl-3-indolyl)-4-(1-methyl-6-nitro-3-indolyl)-1H-pyrrole-2,5-dione |
| Ro-31-7453 |