Mito-apocynin (C2)

Modify Date: 2024-01-31 17:41:00

Mito-apocynin (C2) Structure
Mito-apocynin (C2) structure
Common Name Mito-apocynin (C2)
CAS Number 1254044-41-1 Molecular Weight 536.40
Density N/A Boiling Point N/A
Molecular Formula C28H27BrNO3P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mito-apocynin (C2)


Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect[1].

 Names

Name Mito-apocynin (C2)

 Mito-apocynin (C2) Biological Activity

Description Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect[1].
Related Catalog
In Vivo Mito-apocynin (C2) (3 mg/kg; p.o.; daily for 12 days) exhibits antineuroinflammatory effect[1]. Animal Model: MPTP mice model of Parkinson’s Disease[1] Dosage: 3 mg/kg Administration: Oral gavage; daily for 12 days Result: Significantly attenuated MPTP-induced glial cell activation, proinflammatory cytokine upregulation, inducible nitric oxide synthase, and NOX2 components (gp91phox).
References

[1]. Zielonka J, et al. Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev. 2017 Aug 9;117(15):10043-10120.

 Chemical & Physical Properties

Molecular Formula C28H27BrNO3P
Molecular Weight 536.40
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