DBCO-Amine
DBCO-Amine structure
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Common Name | DBCO-Amine | ||
|---|---|---|---|---|
| CAS Number | 1255942-06-3 | Molecular Weight | 276.33200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of DBCO-AmineDBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
| Name | Azadibenzocylooctyne-amine |
|---|---|
| Synonym | More Synonyms |
| Description | DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Molecular Formula | C18H16N2O |
|---|---|
| Molecular Weight | 276.33200 |
| Exact Mass | 276.12600 |
| PSA | 46.33000 |
| LogP | 3.04710 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
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Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.
J. Am. Chem. Soc. 11th ed., 132 , 3688-3690, (2010) Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The react... |
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Copper-free click chemistry for dynamic in vivo imaging.
Proc. Natl. Acad. Sci. U. S. A. 43th ed., 104 , 16793-16797, (2007) Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes of biomolecules such as glycans and lipids... |
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Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.
Angew. Chem. Int. Ed. Engl. 47 , 2253-2255, (2008)
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| Dibenzocyclooctyne-amine |
| DBCO-NH2 |
| DBCO-amine |
| ADIBO-AMINE |