DBCO-PEG4-Biotin
DBCO-PEG4-Biotin structure
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Common Name | DBCO-PEG4-Biotin | ||
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| CAS Number | 1255942-07-4 | Molecular Weight | 749.916 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1062.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C39H51N5O8S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 596.3±34.3 °C | |
Use of DBCO-PEG4-BiotinDBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative containing a biotin group and 4 PEGs. DBCO-PEG4-Biotin is a versatile biotinylation reagent used for the introduction of a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction[1]. |
| Name | N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-17-oxo-21-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13-tetraoxa-16-azahenicosan-1-amide |
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| Synonym | More Synonyms |
| Description | DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative containing a biotin group and 4 PEGs. DBCO-PEG4-Biotin is a versatile biotinylation reagent used for the introduction of a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction[1]. |
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| Related Catalog | |
| In Vitro | The alkyne group can react with azide moiety in copper-free Click Chemistry reaction to form a stable triazole linkage. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1062.4±65.0 °C at 760 mmHg |
| Molecular Formula | C39H51N5O8S |
| Molecular Weight | 749.916 |
| Flash Point | 596.3±34.3 °C |
| Exact Mass | 749.345825 |
| PSA | 181.86000 |
| LogP | 1.72 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.620 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
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Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.
J. Am. Chem. Soc. 11th ed., 132 , 3688-3690, (2010) Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The react... |
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Copper-free click chemistry for dynamic in vivo imaging.
Proc. Natl. Acad. Sci. U. S. A. 43th ed., 104 , 16793-16797, (2007) Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes of biomolecules such as glycans and lipids... |
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A comparative study of bioorthogonal reactions with azides.
ACS Chem. Biol. 10th ed., 1 , 644-648, (2006) Detection of metabolites and post-translational modifications can be achieved using the azide as a bioorthogonal chemical reporter. Once introduced into target biomolecules, either metabolically or th... |
| N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-17-oxo-21-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13-tetraoxa-16-azahenicosan-1-amide |
| 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[19-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-15,19-dioxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)- |