VU 0409106
Modify Date: 2024-01-11 17:59:42
VU 0409106 structure
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Common Name | VU 0409106 | ||
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| CAS Number | 1276617-62-9 | Molecular Weight | 330.337 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H11FN4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU 0409106VU0409106 is a potent and selective mGlu5 negative allosteric modulator (NAM) with an IC50 of 24 nM. VU0409106 shows anxiolytic effects in rat models in a concentration-dependent manner. VU0409106 also penetrates the blood-brain barrier (BBB)[1][2]. |
| Name | 3-Fluoro-N-(4-methyl-1,3-thiazol-2-yl)-5-(5-pyrimidinyloxy)benzamide |
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| Synonym | More Synonyms |
| Description | VU0409106 is a potent and selective mGlu5 negative allosteric modulator (NAM) with an IC50 of 24 nM. VU0409106 shows anxiolytic effects in rat models in a concentration-dependent manner. VU0409106 also penetrates the blood-brain barrier (BBB)[1][2]. |
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| Related Catalog | |
| Target |
mGlu5:24 nM (IC50) |
| In Vivo | VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1]. Animal Model: CD-1 mice[1] Dosage: 10 mg/kg (10% Tween 80 formulation) Administration: Intraperitoneal injection. Result: 1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice[1]. IP (10 mg/kg) Plasma Tmax (h) 0.25 Plasma Cmax (ng/mL) 1450 Brain Tmax (h) 0.25 Brain Cmax (ng/mL) 1350 AUCplasma (ng/mL•h) 702 AUCbrain (ng/mL•h) 696 B/P ratio 0.99 |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C15H11FN4O2S |
| Molecular Weight | 330.337 |
| Exact Mass | 330.058685 |
| LogP | 3.63 |
| Index of Refraction | 1.664 |
| Benzamide, 3-fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)- |
| MFCD29081178 |
| 3-Fluoro-N-(4-methyl-1,3-thiazol-2-yl)-5-(5-pyrimidinyloxy)benzamide |