Topiramate D12

Modify Date: 2025-08-24 06:10:22

Topiramate D12 structure	Common Name	Topiramate D12
	CAS Number	1279037-95-4	Molecular Weight	351.436
	Density	1.3±0.1 g/cm3	Boiling Point	438.7±55.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₉D₁₂NO₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	219.1±31.5 °C
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Use of Topiramate D12

Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].

Name	{(3aS,5aR,8aR,8bS)-2,2,7,7-Tetrakis[(2H3)methyl]tetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl}methyl sulfamate
Synonym	More Synonyms

Description	Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	GluR5 receptor[1]; GABAergic[2]; Kainate/AMPA[2]; Sodium channel[2]; Calcium channel[2]; Potassium channel[2]; Carbonic anhydrase[2]
References	[1]. Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104. [2]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56. [3]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.

Density	1.3±0.1 g/cm3
Boiling Point	438.7±55.0 °C at 760 mmHg
Molecular Formula	C₁₂H₉D₁₂NO₈S
Molecular Weight	351.436
Flash Point	219.1±31.5 °C
Exact Mass	351.174103
LogP	2.97
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.497

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution

{(3aS,5aR,8aR,8bS)-2,2,7,7-Tetrakis[(2H3)methyl]tetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl}methyl sulfamate

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Topiramate D12

Use of Topiramate D12

Names

Topiramate D12 Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.