Upadacitinib

Modify Date: 2024-01-02 10:18:31

Upadacitinib Structure
Upadacitinib structure
 Common Name Upadacitinib
CAS Number 1310726-60-3 Molecular Weight 380.368
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C17H19F3N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Upadacitinib


Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, being developed for the treatment of several autoimmune disorders.

 Names

Name upadacitinib
Synonym More Synonyms

 Upadacitinib Biological Activity

Description Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, being developed for the treatment of several autoimmune disorders.
Related Catalog
Target

IC50: 43 nM (JAK1), 200 nM (JAK2)[1]

In Vitro In biochemical assays, Upadacitinib is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance)[1].. The enhanced selectivity of Upadacitinib for JAK-1 over JAK-2 and JAK-3 may offer an improved benefit–risk profile in patients with RA range[2].
References

[1]. Nakayamada S, et al. Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis. BioDrugs. 2016 Oct;30(5):407-419.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C17H19F3N6O
Molecular Weight 380.368
Exact Mass 380.157257
LogP 3.06
Index of Refraction 1.678

 Safety Information

Hazard Codes Xn

 Synonyms

upadacitinib
UNII-4RA0KN46E0
(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide
(3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
1-Pyrrolidinecarboxamide, 3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-, (3S,4R)-
ABT-494
UNII:4RA0KN46E0
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Chemsrc provides Upadacitinib(CAS#:1310726-60-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Upadacitinib are included as well.>> amp version: Upadacitinib

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