Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Upadacitinib
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Upadacitinib
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DC Chemicals Limited
China
Product Name: Upadacitinib
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Upadacitinib
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Upadacitinib
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1310726-60-3

1310726-60-3 structure

1310726-60-3 structure

Name: Upadacitinib
Chemical Name: upadacitinib
CAS Number: 1310726-60-3
Molecular Formula: C₁₇H₁₉F₃N₆O
Molecular Weight: 380.368
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2018-09-01 19:16:01
Modify Date: 2024-01-02 10:18:31
Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, being developed for the treatment of several autoimmune disorders.

Name	upadacitinib
Synonyms	upadacitinib UNII-4RA0KN46E0 (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide 1-Pyrrolidinecarboxamide, 3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-, (3S,4R)- ABT-494 UNII:4RA0KN46E0

Description	Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, being developed for the treatment of several autoimmune disorders.
Related Catalog	Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	IC50: 43 nM (JAK1), 200 nM (JAK2)[1]
In Vitro	In biochemical assays, Upadacitinib is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance)[1].. The enhanced selectivity of Upadacitinib for JAK-1 over JAK-2 and JAK-3 may offer an improved benefit–risk profile in patients with RA range[2].
References	[1]. Nakayamada S, et al. Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis. BioDrugs. 2016 Oct;30(5):407-419.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₇H₁₉F₃N₆O
Molecular Weight	380.368
Exact Mass	380.157257
LogP	3.06
Index of Refraction	1.678

Hazard Codes	Xn