CP-96345

Modify Date: 2024-01-09 19:03:35

CP-96345 structure	Common Name	CP-96345
	CAS Number	132746-60-2	Molecular Weight	412.57
	Density	1.15g/cm3	Boiling Point	541.5ºC at 760 mmHg
	Molecular Formula	C₂₈H₃₂N₂O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	281.3ºC
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of CP-96345

CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation[1].

Name	(2S,3S)-2-benzhydryl-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
Synonym	More Synonyms

Description	CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	Tachykinin, Substance P receptor[1]
References	[1]. Lembeck F, et al. The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br J Pharmacol. 1992;105(3):527-530.

Density	1.15g/cm3
Boiling Point	541.5ºC at 760 mmHg
Molecular Formula	C₂₈H₃₂N₂O
Molecular Weight	412.57
Flash Point	281.3ºC
Exact Mass	412.25100
PSA	24.50000
LogP	5.40850
Vapour Pressure	8.65E-12mmHg at 25°C
Index of Refraction	1.633
Storage condition	-20°C

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335-H400
Precautionary Statements	P261-P273-P305 + P351 + P338
Hazard Codes	Xi
RIDADR	UN 3077 9 / PGIII

Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.

Br. J. Pharmacol. 172(3) , 924-39, (2015)

Spinal voltage-gated calcium channels (VGCCs) are pivotal regulators of painful and inflammatory alterations, representing attractive therapeutic targets. We examined the effects of epidural administr...

Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.

Am. J. Physiol. Lung Cell. Mol. Physiol. 294(5) , L912-20, (2008)

This study aimed to 1) assess whether substance P (SP) acts via neurokinin (NK)-1 and NK-2 receptors to stimulate neurogenic inflammation (indicated by formation of ICAM-1 expression and oxidative str...

An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.

Am. J. Pathol. 169(5) , 1663-70, (2006)

Opioid withdrawal is a crucial and recurring event during the course of opioid abuse that has a negative impact on the immune system. In this study, we investigated whether abrupt withdrawal (AW) or p...

(2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine

CP 96,345

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CP 96345
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: CP-96345
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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