Biotin-PEG4-PFP ester

Modify Date: 2024-01-10 03:28:24

Biotin-PEG4-PFP ester Structure
Biotin-PEG4-PFP ester structure
Common Name Biotin-PEG4-PFP ester
CAS Number 1334172-58-5 Molecular Weight 657.647
Density 1.3±0.1 g/cm3 Boiling Point 804.9±65.0 °C at 760 mmHg
Molecular Formula C27H36F5N3O8S Melting Point N/A
MSDS N/A Flash Point 440.6±34.3 °C

 Use of Biotin-PEG4-PFP ester


Biotin-PEG4-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name Pentafluorophenyl 17-oxo-21-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13-tetraoxa-16-azahenicosan-1-oate
Synonym More Synonyms

 Biotin-PEG4-PFP ester Biological Activity

Description Biotin-PEG4-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 804.9±65.0 °C at 760 mmHg
Molecular Formula C27H36F5N3O8S
Molecular Weight 657.647
Flash Point 440.6±34.3 °C
Exact Mass 657.214355
LogP 0.97
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.503

 Synonyms

Pentafluorophenyl 17-oxo-21-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13-tetraoxa-16-azahenicosan-1-oate
4,7,10,13-Tetraoxa-16-azaheneicosan-1-oic acid, 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-, 2,3,4,5,6-pentafluorophenyl ester