Cbz-NH-PEG6-C2-acid

Modify Date: 2024-01-23 11:38:09

Cbz-NH-PEG6-C2-acid Structure
Cbz-NH-PEG6-C2-acid structure
Common Name Cbz-NH-PEG6-C2-acid
CAS Number 1334177-80-8 Molecular Weight 487.541
Density 1.2±0.1 g/cm3 Boiling Point 627.2±55.0 °C at 760 mmHg
Molecular Formula C23H37NO10 Melting Point N/A
MSDS N/A Flash Point 333.1±31.5 °C

 Use of Cbz-NH-PEG6-C2-acid


Cbz-NH-PEG6-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-Oxo-1-phenyl-2,7,10,13,16,19,22-heptaoxa-4-azapentacosan-25-oic acid
Synonym More Synonyms

 Cbz-NH-PEG6-C2-acid Biological Activity

Description Cbz-NH-PEG6-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 627.2±55.0 °C at 760 mmHg
Molecular Formula C23H37NO10
Molecular Weight 487.541
Flash Point 333.1±31.5 °C
Exact Mass 487.241760
LogP -0.25
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.503

 Synonyms

2,7,10,13,16,19,22-Heptaoxa-4-azapentacosan-25-oic acid, 3-oxo-1-phenyl-
3-Oxo-1-phenyl-2,7,10,13,16,19,22-heptaoxa-4-azapentacosan-25-oic acid
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