Ara-F-NAD+

Modify Date: 2024-01-09 00:33:22

Ara-F-NAD+ Structure
Ara-F-NAD+ structure
Common Name Ara-F-NAD+
CAS Number 133575-27-6 Molecular Weight 665.42
Density N/A Boiling Point N/A
Molecular Formula C21H26FN7O13P2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ara-F-NAD+


Ara-F-NAD+, an arabino analogue of NAD+, is a potent, slow-binding CD38 NADase inhibitor, with a Ki of 169 nM[1][2].

 Names

Name Ara-F-NAD+

 Ara-F-NAD+ Biological Activity

Description Ara-F-NAD+, an arabino analogue of NAD+, is a potent, slow-binding CD38 NADase inhibitor, with a Ki of 169 nM[1][2].
Related Catalog
In Vitro The leucoyte surface antigen CD38 has been shown to be an ecto-enzyme with multiple catalytic activities. It is principally a NAD+ glycohydrolase that transforms NAD+ into ADP-ribose and nicotinamide. CD38 is also able to produce small amounts of cyclic ADP-ribose (ADP-ribosyl cyclase activity) and to hydrolyse this cyclic metabolite into ADP-ribose (cyclic ADP-ribose hydrolase activity)[1].
References

[1]. Berthelier V, et al. Human CD38 is an authentic NAD(P)+ glycohydrolase. Biochem J. 1998;330 ( Pt 3)(Pt 3):1383-1390. doi:10.1042/bj3301383

[2]. Wang S, et al. Design, synthesis and SAR studies of NAD analogues as potent inhibitors towards CD38 NADase. Molecules. 2014;19(10):15754-15767. Published 2014 Sep 29.

 Chemical & Physical Properties

Molecular Formula C21H26FN7O13P2
Molecular Weight 665.42
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