CM-4620
Modify Date: 2024-01-09 16:08:19
CM-4620 structure
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Common Name | CM-4620 | ||
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| CAS Number | 1713240-67-5 | Molecular Weight | 421.757 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 444.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H11ClF3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 222.5±28.7 °C | |
Use of CM-4620CM-4620 is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM, 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively. |
| Name | N-[5-(6-Chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2-pyrazinyl]-2-fluoro-6-methylbenzamide |
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| Synonym | More Synonyms |
| Description | CM-4620 is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM, 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively. |
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| Related Catalog | |
| Target |
IC50: 119 nM (Orai 1/STIM1), 895 nM (Orai 1/STIM1)[1]. |
| In Vitro | It is determined that CM-4620 (compound 1) inhibits Orai 1/STIM1 channels with an IC50 of 119 nM, and Orai2/STIM1 channels with an IC50 of 895 nM. It is more potent on Orai1 than Orai2-type CRAC channels. In human PBMCs, CM-4620 potently inhibits release of multiple cytokines which play important roles in T cells (IC50s, IFN γ: 138 nM, IL-4: 879 nM, IL-6: 135 nM, IL-1β: 240 nM, IL-10: 303 nM, TNFα: 225 nM, IL-2: 59 nM, IL-17 120 nM)[1]. |
| In Vivo | Mouse PACs are treated with CRAC inhibitors CM-4620 or GSK-7975A and monitored for their rate of Calcium uptake. Both CRAC inhibitors reduce the rate of store-operated Calcium entry into the ER to 50% of controllevels upon treatment with 700 nM of inhibitor. CM-4620 blocks 100% of reuptake at 10 mM[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 444.4±45.0 °C at 760 mmHg |
| Molecular Formula | C19H11ClF3N3O3 |
| Molecular Weight | 421.757 |
| Flash Point | 222.5±28.7 °C |
| Exact Mass | 421.044098 |
| LogP | 4.93 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.639 |
| Storage condition | 2-8℃ |
| Benzamide, N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2-pyrazinyl]-2-fluoro-6-methyl- |
| N-[5-(6-Chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2-pyrazinyl]-2-fluoro-6-methylbenzamide |
| CM-4620 |