CM 572

Modify Date: 2024-08-09 17:20:17

CM 572 Structure
CM 572 structure
Common Name CM 572
CAS Number 1121932-91-9 Molecular Weight 426.51
Density N/A Boiling Point N/A
Molecular Formula C22H23FN4O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CM 572


A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors; induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM, also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells.

 Names

Name CM 572

 CM 572 Biological Activity

Description A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors; induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM, also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells.
References References 1. Nicholson H, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. 2. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. View Related Products by Target Sigma Receptor

 Chemical & Physical Properties

Molecular Formula C22H23FN4O2S
Molecular Weight 426.51
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