CM 572
Modify Date: 2024-08-09 17:20:17
CM 572 structure
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Common Name | CM 572 | ||
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| CAS Number | 1121932-91-9 | Molecular Weight | 426.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23FN4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CM 572A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors; induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM, also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells. |
| Name | CM 572 |
|---|
| Description | A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors; induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM, also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells. |
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| References | References 1. Nicholson H, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. 2. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. View Related Products by Target Sigma Receptor |
| Molecular Formula | C22H23FN4O2S |
|---|---|
| Molecular Weight | 426.51 |