SB218078

Modify Date: 2025-08-20 19:50:28

SB218078 structure	Common Name	SB218078
	CAS Number	135897-06-2	Molecular Weight	393.39400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₅N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SB218078

SB-218078 is a potent, selective and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest[1][2][3].

Name	sb 218078
Synonym	More Synonyms

Description	SB-218078 is a potent, selective and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest[1][2][3].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Checkpoint Kinase (Chk) Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> TGF-beta/Smad >> PKC
Target	Chk1:15 nM (IC50) Cdc2:250 nM (IC50) PKC:1000 nM (IC50)
In Vitro	SB-218078 (2.5-5 μM; 18 hours; HeLa cells) treatment abrogates G2 cell cycle arrest caused by either γ-irradiation or a topoisomerase I Topotecan inhibition[1]. SB-218078 (500-625 μM; 96 hours; HeLa and HT-29 cells) treatment significantly increases the cytotoxicity of DNA damage [1]. Cell Cycle Analysis[1] Cell Line: HeLa cells Concentration: 2.5 μM, 5 μM Incubation Time: 18 hours Result: Abrogated G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Cell Cytotoxicity Assay[1] Cell Line: HeLa and HT-29 cells Concentration: 500 nM, 625 nM Incubation Time: 96 hours Result: Enhanced cytotoxicity of DNA damage.
In Vivo	SB-218078 (5 mg/kg; intraperitoneal injection; for 16 hours; C57/Bl6 mice) treatment could promote a strong increase of γ-H2AX and apoptosis throughout the lymphoma, while having no effect on a healthy spleen in Myc-induced lymphomas mouse model[2]. Animal Model: C57/Bl6 mice injected with ARF-/- lymphomas[2] Dosage: 5 mg/kg Administration: Intraperitoneal injection; for 16 hours Result: Promoted a strong increase of γ-H2AX and apoptosis throughout the lymphoma.
References	[1]. Jackson JR, et al. An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Res. 2000 Feb 1;60(3):566-72. [2]. Murga M, et al. Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-1335. [3]. Preet R, et al. Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade. Biochem Pharmacol. 2016 Apr 1;105:23-33.

Molecular Formula	C₂₄H₁₅N₃O₃
Molecular Weight	393.39400
Exact Mass	393.11100
PSA	69.02000
LogP	4.36310
Index of Refraction	1.97

hms3229o08

SB218078

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SB218078
Price: Check
Purity: 98.0%
Delivery: 10 Day
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DC Chemicals Limited
China
Product Name: SB218078
Price: $480.0/100mg $850.0/250mg $1700.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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SB218078

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.